Study Of Molecular Docking On Compounds With Potential As Anti-Inflammatory

Andien Ravelliani; Hasna' Nisrina; Lala Komala Sari; Marisah Marisah; Annastya Eka  Agustin; Dhavina Maharani; Marsah Rahmawati Utami; Lina Nurfadhila

Authors

Andien Ravelliani Universitas Singaperbangsa Karawang
Hasna' Nisrina Universitas Singaperbangsa Karawang
Lala Komala Sari Universitas Singaperbangsa Karawang
Marisah Marisah Universitas Singaperbangsa Karawang
Annastya Eka Agustin Universitas Singaperbangsa Karawang
Dhavina Maharani Universitas Singaperbangsa Karawang
Marsah Rahmawati Utami Universitas Singaperbangsa Karawang
Lina Nurfadhila Universitas Singaperbangsa Karawang

Keywords:

Molecular Docking, Anti-Inflammatory, COX-1 and COX-2

Abstract

Inflammation is a protective response caused by damage to certain tissues. Anti-inflammatory is a substance or drug used to treat redness, increased body temperature, swelling, pain and loss of function of an organ. Steroid and non-steroidal anti-inflammatory drugs have many side effects, so studies are needed to develop new drugs to minimize side effects and improve therapeutic effects. The method used is literature review from journals and articles obtained from Google Scholar in 15 journals. The purpose of the literature review is to find out the study of the development of new drugs from several compounds that have potential as anti-inflammatories. Secondary metabolites that have potential as anti-inflammatory include essential oils, flavonoids, alkaloids, terpenoids, and anthocyanins. Secondary metabolites will interact with the cyclooxygenase (COX) enzyme which is the main mediator of inflammation. The results obtained from the 15 compounds contain these secondary metabolites so they have the potential as anti-inflammatory.

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