The Effectiveness of Ethanol Extract Gel of Cumin Leaves (Plectranthus Amboinicus) toward White Male Rat (Rattus Novergicus)
Keywords:
Extract Ethanol, white cumin Leaves (Plectranthus amboinicus), gel, wound, White Male Rat (Rattus Novergicus)Abstract
The leavers of white cumin (Plectranthus amboinicus) are a species of the family. Lamiaceae, previously known as Coleus amboinicus, contains quertesin compounds that are effective in healing wounds. The purpose of this study was to determine the extract of the leaves of white cumin (Plecranthus amboinicus) can be formulated for gel readiness and can affect the healing of cuts in white male rats (Rattus novergicus). The research method was laboratory experimental with the One Group Pretest- posttest research design. The leaves of white cumin (Plectranthus amboinicus) were extracted using 96% ethanol by maceration process and made into a gel form with a concentration of 3%, 5 %, and 7%. Evaluation of the physical and chemical stability of the gel before and after the cycling test for 6 cycles. This study used 15 male white rats divided into 5 groups, each group consisting of 3 and wounded with a depth of 2 cm and a length of 3 cm. the first male white rats were given a gel concentration of 3 %, the second 5%, the third 7 %, the fourth was given a gel without extract (negative control) and fifth was given 10 of octenilin gel (positive control). The incision length was measured on day 1,3,6,9,11,13 then data analysis used the ANOVA and SPSS 22 version. The results showed that leavers of white cumin (Plectranthus amboinicus) extract was p˂ 0,05, so there was a significant difference between each treatment. It can be concluded that gel readiness can be formulated and can affect wound healing in white male rats (Rattus novergicus).
References
M. Tetti, “Ekstraksi, pemisahan senyawa, dan identifikasi senyawa aktif,” J. Kesehat., vol. 7, no. 2, 2014, [Online]. Available: https://journal3.uin-alauddin.ac.id/index.php/kesehatan/article/view/55
S. Suroowan, K. B. Pynee, and M. F. Mahomoodally, “A comprehensive review of ethnopharmacologically important medicinal plant species from Mauritius,” South African J. Bot., vol. 122, pp. 189–213, 2019, doi: 10.1016/j.sajb.2019.03.024.
D. D. Wadikar and P. E. Patki, “Coleus aromaticus: a therapeutic herb with multiple potentials,” J. Food Sci. Technol., vol. 53, no. 7, pp. 2895–2901, 2016, doi: 10.1007/s13197-016-2292-y.
R. Alyidrus, A. Nurhikma, and N. Kasman, “Aktivitas Antibakteri Ekstrak Etanol Batang Laruna (Chromolaena Odorata L.) Terhadap Staphylococcus Aureus Dan Pseudomonas Aeruginosa,” INHEALTH Indones. Heal. J., vol. 1, no. 1, pp. 62–70, 2022, [Online]. Available: https://jurnal-eureka.com/index.php/inhealth/article/view/20
N. L. Alydrus and N. Khofifahl, “Efektifitas Antibakteri Ekstrak Daun Sirih Hijau (Piper Betle L) Terhadap Staphylococcus Aureus,” INHEALTH Indones. Heal. J., vol. 1, no. 1, pp. 56–61, 2022, [Online]. Available: https://jurnal-eureka.com/index.php/inhealth/article/view/23
S. Wijayanti and F. Mustamin, “Formulasi dan Uji Antibakteri Masker Peel-Off Ekstrak Daun Gulma Siam ( Chromolaena odorata L .) Terhadap Propionibacterium Acnes Formulation and Anti-bacterial Test on Peel-off Mask from Gulma Siam ( Chromolaena odorata L .) against Propionibacterium Acn,” J. Farm. Indones., vol. 19, no. 2, pp. 348–362, 2022.
L. L. Zhang, S. S. Feng, J. G. Xu, and J. G. Xu, “Profile of phytochemicals and antioxidant activities of different solvent extracts of cumin seeds,” Appl. Mech. Mater., vol. 675–677, pp. 1612–1616, 2014, doi: 10.4028/www.scientific.net/AMM.675-677.1612.
R. S. Lailatul Muniroh, Santi Martini, Triska Susila Nindya, “Pengaruh Pemberian Zat Besi dan Asam Folat Dibandingkan dengan Multivitamin dan Mineral pada Pekerja Wanita Usia Subur di Agroindustri Nanas,” Makara Seri Kesehat., vol. 17, no. 1, pp. 17–25, 2013, doi: 10.7454/msk.v17i1.xxxx.
F. Tafzi, N. Andarwulan, P. E. Giriwonob, F. Nur, and A. Dewid, “Efficacy Methanol Extract of Torbangun Leaves (Plectranthus amboinicus) in Epithelial Cell of Mammary Gland MCF-12A),” J. Ilmu Kefarmasian Indones., vol. 15, no. 1, pp. 17–24, 2016.
E. S. B. Nuraminah Nasution, Luthfi A. M. Siregar*, “Vegetative Growth Characteristic, Sterols and Chlorophyll Content of Some Accessions Indian Borage (Plectranthus amboinicus (Lour.) Spreng),” J. Agroekoteknologi FP USU, vol. 5, no. 1, pp. 26–32, 2017.
S. Marina, “Plectranthus amboinicus (LOUR.) Speng Sebagai Bahan Pangan dan Obat Serta Bioaktivitasnya. Universitas Kristen Indonesia.,” 2018.
R. S. Sundari, A. Kusmayadi, R. Hidayati, and A. Arshad, “INCREASING SALTY EGGS QUALITY AND CONSUMER PREFERENCE BY DECREASING ODOR WITHIN ANTIOXIDANT OF Plectranthus amboinicus L SPRENG,” Mimb. Agribisnis J. Pemikir. Masy. Ilm. Berwawasan Agribisnis, vol. 6, no. 2, p. 853, 2020, doi: 10.25157/ma.v6i2.3590.
H. Purnama, Sriwidodo, and S. Ratnawulan, “Review Sistematika: Proses Penyembuhan dan Perawatan Luka,” Farmaka, vol. 15, no. 2, pp. 255–256, 2017.
J. Wyatt, Forensic Medicine. New York: Oxford University. 2011.
R. M. Halim, “Uji Efek Penyembuhan Luka Sayat Ekstrak Etanol Daun Kecombrang (Etlingera elatior) dalam Bentuk Sediaan Gel terhadap Kelinci (Oryctolagus cuniculus). (Doctoral dissertation, Universitas Islam Negeri Alauddin Makassar),” 2014.
R. Pandey, D. Kumar, and A. Ahmad, “Nigella sativa seed extracts prevent the glycation of protein and DNA,” Curr. Perspect. Med. Aromat. Plants, vol. 1, pp. 1–7, 2018, [Online]. Available: https://dergipark.org.tr/en/pub/cupmap/issue/38636/425212
F. W. Kurniawan, “Optimasi Natrium Alginat dan Na-CMC Sebagai Gelling Agent Pada Sediaan Gel Antiinflamasi Ekstrak Daun Petai Cina (Leuucaena leucocephala (Lam.) de Wit) Dengan Aplikasi Desain Faktorial. Universitas Sanata Dharma Yogyakarta,” 2013.
R. Muniroh, L., Martini, S., Nindya, TS., Solfaine, “Efek Anti Radang dan Toksisitas Akut Ekstrak Daun Jintan (Plectranthus amboinicus) pada Tikus yang Diinduksi Arthritis,” Makara Seri Kesehatan, 2013, 17(1) hlm. 33–40, 2013.
R. Marianne, M., Lestari, D., Sukandar, E. Y., Kurniati, N. F., & Nasution, “Antidiabetic Activity of Leaves Ethanol Extract Chromolaena odorata (L.) RM King on Induced Male Mice with Alloxan Monohydrate,” J. Nat. 14(1), 2014, [Online]. Available: http://www.jurnal.unsyiah.ac.id/natural/article/view/1382
G. C. Ramadhan, S. Hastuti, P. Bhakti, and M. Sukoharjo, “Uji Daya Analgetik Ekstrak Etanol Daun Jinten (Coleus Amboinicus L.) Pada Mencit Dengan Metode Rangsang Kimia (Analgesic Power Test Of Ethanol Extract Of Jinten Leaves (Coleus Amboinicus L.) On Mice With Chemical Stimulation Methods),” IJMS-Indonesian J. Med. Sci., vol. 3, no. 2, pp. 2355–1313, 2016.
