FORMULATION OF HAND SANITIZER GEL PREPARATION COMBINATION OF NEMBA LEAF (AZADIRACHTAINDICAA.JUSS) ETHANOL EXTRACT OF AND EXTRACT OF ALOE VERA (ALOE VERA)AGAINS STAPYLOCOCCUCAUREUS BACTERIA
Keywords:
Neem Leaf, Aloe Vera, Antiseptic, Staphylococcus AureusAbstract
The use of hand antiseptics in the form of gel preparations which are more popular with the namepreparations hand sanitizer usually contain antiseptics in the form of synthetic chemicals which are relatively expensive and often cause skin health problems, such as dry skin. The leaves of the neem plant and aloe vera gel have been shown to be able to treat several diseases, one of which is being able to be a companion drug for antibacterial treatment. The method used in this research is experimental method because it is intended to determine the effect or relationship between the independent variables called treatment factors, namely thegel formulation Hand Sanitizer from a combination of neem leaves and aloe vera gel with concentrations of 5%, 10%, and 15%, with the dependent variable called the observation factor, namely the test. Organoleptic, pH, homogeneity, dispersion test, irritation test and antibacterial activity tes. The results obtained from this study are that neem leaf ethanol extract and aloe vera gel can be formulated intopreparations hand sanitizer gelwith concentrations of 5%, 10% and 15%, with homogeneous preparations, pH around 6.68-7.03, with dispersion ranges from 4.4cm - 5.5 cm, and stable at 4 weeks of storage.. Results preparations hand sanitizers containing ethanol extract of neem leaves 15% provides a strong barrier against Staphylococcus aureus was 13.80 ± 0.29 mm.
References
Astuti, E. K. (2020). The Influence Of Health Education With Audio Visual Media On Clean And Healthy Living Behavior (PHBS) In Grade III-V Students At Wanurojo Kemiri Purworejo State Elementary School. Jurnal EduHealth, 10(2), 21–31.
A.Lana,2017. Penentuannilai FICI kombinasi ekstrak etanol kulit daun lidah buaya dan gentamisin sulfat terhadap bakteri Escherichia Coli. Pharm Sci Res ISSN 2407-2354.
Ansel, H.C., 1989, Pengantar Bentuk Sediaan Farmasi, diterjemahkan oleh Farida Ibrahim, Asmanizar, Lis Aisyah, Edisi keempat, 255-271, 607-608, 700, Jakarta, UI Press
Ambrawati, 2011. Mimba sebagai Antibakteri, Antifungi Dan Biopestisida. Jurnal Kesehatan, ISSN1979-7621, Vol 4, No. 2, Desember 2011 : 154-163.
CCRC, 2020. Mimba. IJCC. Cancer Chemoprevention Researrch Center. UGM.
Carolia N, Sukohar A. Pengaruh Pemberian Ekstrak Lidah Buaya Terhadap Jumlah Makrofag pada radang Mukosa Mulut Tikus Putih Jantan Galur Sprague Dawley. JK Unila. 2016: 1(2) : 243-6.
Departemen Kesehatan RI. (1995). Materia Medika Indonesia. Jilid VI. Jakarta: Departemen Kesehatan RI.
Ditjen POM. (1985). FormulariumKosmetik Indonesia. Jakarta :DepartemenKesehatan RI.
Eko, 2019. UjiAktivitasAntibakteriekstrakdaunmimba, sambangdarahdannilamterhadap mycobacterium tuberculosis. Mahakam Nursing Journal. Vol 2, no 6, nov 2019
Ariyanisb, hidayati h. Penambahan gel lidah buaya sebagai anti bakteri pada sabun mandi cair berbahan dasar minyak kelapa. J ind has perkeb. 2018;13(1):11–8.
Gilman, A. G.2008. Dasar Farmakologi Terapi. Edisi 10.. Jakarta: EGC
Maharani, 2017. Uji Aktivitas Anti bakteri Kombinasi Ekstrak Etanol daun Kelor dan daun salam.Mulawarman Pharmaceuticals Comferences. Issn : 2614-4778 november 2017
Jawetz, Melnick, dan Adelberg., 2013. Mikrobiologi Kedokteran. Ed. 25. EGC: Jakarta
Nazir F, Zahari A, Anas E. Pengaruh pemberian gel lidah buaya terhadap jarak pinggir luka pada tikus wistar. J KesehatanAndalas 2015 : 4 (3) : 827-32
Bahar m, yusmaini h. Efek antimikroba ekstrak lidah buaya (aloe vera) terhadap isolat bakteri penyebab acne vulgaris secara invitro. J profesimed jkedoktdankesehat. 2018;11(2).
Yulinar, Husain, D. R., dan Abdullah, A. (2011). Bioaktivitas Minyak Atsiri Rimpang Lengkuas Merah Alpinia purpurata K. Schum terhadap pertumbuhan Bakteri Bacillus cereus dan Pseudomonas aerus dan Pseudomonas aeruginosa. Makassar: Universitas Hasanuddin. Halaman 3-4.
