The Effect Of Giving Pegagan (Centella Asiatica) Ethanol Extract On Incised Wound Healing In White Rats (Rattus Norvegicus)
Keywords:
Centella asiatica, Ethanol extract of Pegagan, Incised wound, wound healing, DurationAbstract
This study aims to determine the effect of giving Centella asiatica on incised wound healing through the treatment of Centella asiatica on white rats (Rattus norvegicus). This study uses Experimental method in the form of a post-test only group design to determine the effect of Centella asiatica ethanol extract on the healing time of incised wound in white rats (Rattus norvogicus). The sample used in this study was 20 white rats divided into five treatment groups. Data analysis used quantitative analysis with helped of SPSS 29 software. The data test consisted of normality, homogeneity, and one way ANOVA test. The result showed 10% Povidone iodine, vaseline, 10% ointment of Centella asiatica ethanol extract, 15% ointment of Centella asiatica ethanol extract, and 25% ointment of Centella asiatica ethanol extract had the same effect on incised wound healing in white rats (Rattus norvogicus). Intervention with 10% Povidone iodine had average healing time of 12,75 days; intervention with 10% ointment of Centella asiatica ethanol extract had average healing time of 10 days; intervention with 15% ointment of Centella asiatica ethanol extract had average healing time of 8,75 days; and intervention with 25% ethanol extract Centella asiatica had average healing time of 12,75 days. The normaly test shows that the entire group has a significant value of p>0,05, so it says that the data is normally distributed. The homogeneity test shows an overall significance of p>0,05, so the data is nuanced and homogeneous. The ANOVA test showed a significance of p = 0,152, so the value of p >0,05, meant that there was so significant difference between groups. This study proved that the application of Centella asiatica ethanol extract ointment can be used as an alternative in the treatment of incised wound, such as post-section caesarean wound care.
References
Ansel, H. C. (1989). Pengantar Bentuk Sediaan Farmasi. UI Press.
Balqis, U., Masyitha, D., & Febriana, F. (2014). Proses Penyembuhan Luka Bakar dengan Gerusan Daun Kedondong (Spondias dulcis F.) dan Vaselin pada Tikus Putih (Rattus norvegicus) secara Histopatologis. Jurnal Medika Veterinaria, 8(1), 1–14.
Galomat, D. E., de Queljoe, E., & Datu, O. . (2021). pengaruh Pemberian Salep Ekstrak Daun Pegagan (Centella asiatica) (L.) Urb. Terhadap Penyembuhan Luka Sayat Tikus Putih Jantan (Rattus norvegicus). PHARMACON, 10(4), 1205–1214.
Harsa, I. M. . (2020). Efek Pemberian Ekstrak Daun Pegagan (Centella asiatica) terhadap Penyembuhan Luka Sayat pada Tikus Putih Jantan (Rattus norvegicus) Galur Wistar. Jurnal Ilmiah Kedokteran Wijaya Kusuma, 9(1), 21–27.
Nurdiatini, I., Pastiwi, S., & Nurmaningsari, T. (2017). Perbedaan Efek Penggunaan Povidone iodine 10% dengan Minyak Zaitun Terhadap Penyembuhan Luka Robek (Lecerated Wound). Nursing News : Jurnal Ilmiah Keperawatan, 2(1).
Oktaviani, D. J., Widiyastuti, S., Maharani, D. ., Amalia, A. ., Ishak, A. ., & Zuhrotun, A. (2019). Bahan Alami Penyembuh Luka. Majalah Farmasetika, 45–56.
Ramandey, J. M., & Bunei, P. (2021). Identifikasi Tanaman Pegagan (Centela asiatika L.) Sebagai Tanaman Obat Bagi Masyarakat Suku Mee Di Distrik Tigi Timur Kabupaten Deiyai. Jurnal FAPERTANAK: Jurnal Pertanian Dan Peternakan, 23–31.
Seevaratnam, V. (2012). Functional Properties of Centella Asiatica. 4.
Septiani, Y., Puspariki, J., & Farhan, F. (2020). Pembuatan dan Uji Organoleptik Sediaan Gel Daun Pegagan (Centella asiatica L. Urban) dengan Daging Lidah Buaya (Aloe vera) untuk Luka Bakar. Journal of Holistic and Health Sciences, 4(1), 25–30.
Smeltzer, S. C., & BG., B. (2001). Buku Ajar Keperawatan Medikal Bedah. EGC.
Suryanti, & Supriyadi, A. (2008). Pisang, Budi daya, Pengolahan, dan Prospek Pasar (A. Anggara (ed.); 8 (edisi r). Penebar Swadaya.
Sutardi. (2017). Kandungan Bahan Aktif Tanaman Pegagan dan Khasiatnya untuk Meningkatkan Sistem Imun Tubuh. Jurnal Penelitian Dan Pengembangan Pertanian, 35(3), 121. https://doi.org/10.21082/jp3.v35n3.2016.p121-130
Widianingtyas, D. (2013). Pengaruh Perawatan Ekstrak Daun Pegagan (Centella asiatic) dalam Mempercepat Penyembuhan Luka Bakar Derajat 2 Dangkal pada Tikus Putih (Rattus norvegicus) Strain Wistar. Universitas Brawijaya.
Winarto, W. P., & Surbakti, M. (2003). Khasiat dan Manfaat Pegagan : Tanaman Penambah Daya Ingat. Agro Media.
Zheng, C., & Qin, L. (n.d.). Chemical Components of Centella asiatica and their Bioactivities J of Chinese Integrative Medicine. 5(3), 348–351.
