Antifungal Test of Telang Flower Ethanol Extract (Clitoria Ternateal) as a Mouthwash Against Candida

Hendri Andrian; Dendy Murdiyanto; Aprilia Yuanita Anwaristi; Nur Ariska Nugrahani

Authors

Hendri Andrian Universitas Muhammadiyah Surakarta
Dendy Murdiyanto Universitas Muhammadiyah Surakarta
Aprilia Yuanita Anwaristi Universitas Muhammadiyah Surakarta
Nur Ariska Nugrahani Universitas Muhammadiyah Surakarta

Keywords:

Candidacy, Butterfly Pea (Clitoria ternatea L), Mouthwash, Antifungal

Abstract

Candidiasis is a disease of the oral cavity caused by fungal changes Candida albicans from sapophytes to pathogens. CI love albicanslive in the human body as saprophytes and can turn into pathogens if there are risk factors such as poor oral hygiene, low immunity, and other factors. So that preventive action can be done by usingmouthwash that can inhibit the growth of bacteria or fungi, one of which is the use of butterfly pea flower extract. Objective: To determine the effectiveness of ethanol flower extract mouthwash in inhibiting growth Candida albicans. Research methods: This research is a true quantitative experimental laboratory test only control group design with a total of 36 samples consisting of positive control, negative control, and basic mouthwash added with 20%, 30%, 40%, and 50% ethanol extract. Research result: There were significant differences between the butterfly pea flower ethanol groups at concentrations of 20%, 30%, 40%, and 50% to the negative control group. So that the ethanol extract of butterfly pea flowers has inhibitory or antifungal power on growth Candida albicans. Conclusion: Mouthwash ethanol extract of butterfly pea flower concentration of 50% is the best concentration in inhibiting growth Candida albicans compared to other groups.

Author Biographies

Hendri Andrian, Universitas Muhammadiyah Surakarta

Dendy Murdiyanto, Universitas Muhammadiyah Surakarta

Aprilia Yuanita Anwaristi, Universitas Muhammadiyah Surakarta

Nur Ariska Nugrahani, Universitas Muhammadiyah Surakarta

References

K. G. Mitchell, J. A. Bradley, I. M. Ledingham, and D. N. Hamilton, “Candida colonization of the oral cavity.,” Surg. Gynecol. Obstet., vol. 154, no. 6, pp. 870–874, Jun. 1982.

A. Fajri and G. Marlina, “Obat Kumur Untuk Mengatasi Jamur Candida Albicans dan Bakteri Sreptococus Mutans di Rongga Mulut,” J. Tadris Kim., pp. 39–42, 2019.

Paramesti S, M. Rs, and E. Pd, “Evaluasi Efektivitas Antifungi Ekstrak Etanol Bawang Putih (Allium sativum) dan Nistatin secara In Vitro terhadap Candida albicans In Vitro,” J. Mikol. Indones., vol. 3, no. 1, pp. 25–32, 2019, [Online]. Available: www.mikoina.or.id

Kementerian Kesehatan Republik Indonesia, “Laporan Perkembangan HIV AIDS dan Penyakit Menular Seksual (PIMS) Triwulan IV Tahun 2018,” Direktorat Jenderal Pengendali. Penyakit dan Penyehatan Lingkung., pp. 1–30, 2018.

M. Talumewo, C. Mintjelungan, and M. Wowor, “Perbedaan Efektivitas Obat Kumur Antiseptik Beralkohol Dan Non Alkohol Dalam Menurunkan Akumulasi Plak,” Pharmacon, vol. 4, no. 4, pp. 1–8, 2015.

N. R. Putri, R. Afrianti, and Z. Desinta, “Formulasi Obat Kumur Ekstrak Etanol Bawang Dayak (Eleutherine Bulbosa (Mill.) Urb) Dan Uji Efektivitas Anti Jamur Terhadap Pertumbuhan Candida albicans,” J. Akad. Farm. Pray., vol. 3, no. 1, pp. 20–32, 2018, [Online]. Available: http://jurnal3.akfarprayoga.ac.id/index.php/JAFP/article/view/16

S. Rezeki, S. Chismirina, and A. Iski, “Pengaruh Ekstrak Daun Sirih Merah (Piper crocatum) Terhadap Pertumbuhan Candida albicans,” JDS (Journal Syiah Kuala Dent. Soc., vol. 2, no. 1, pp. 52–62, 2017.

L. Angriani, “The Potential of Extract Butterfly Pea Flower (Clitoria ternatea L.) as a Local Natural Dye for Various Food Industry,” Canrea J. Food Technol. Nutr. Culin. J., vol. 2, no. 1, pp. 32–37, 2019, doi: 10.20956/canrea.v2i1.120.

K. S. Budiasih, “Kajian Potensi Farmakologis Bunga Telang (Clitoria ternatea),” Pros. Semin. Nas. Kim., pp. 201–206, 2017, [Online]. Available: https://jurnal.stiabengkulu.ac.id/index.php/jsm/article/view/18%0Afile:///C:/Users/ilmia/Downloads/497-Article Text-1098-1-10-20220501.pdf%0Ahttps://www.prosidingonline.iik.ac.id/index.php/senias/article/view/95

Firman Rezaldi, Eman eman, Fernanda Desmak Pertiwi, Suyamto Suyamto, and Sumarlin US, “Potensi Bunga Telang (Clitoria ternatea L) sebagai Antifungi Candida Albicans, Malasezia Furfur, Pitosprorum Ovale, dan Aspergilus Fumigatus dengan Metode Bioteknologi Fermentasi Kombucha,” J. Ilm. Kedokt. dan Kesehat., vol. 1, no. 2, pp. 1–9, 2022, doi: 10.55606/klinik.v1i2.381.

M. Fahmi, Abdillah R, F. Ady Soesetijo, and D. Kristiana, “Efektivitas Ekstrak Biji Srikaya (Annona squamosa L.) sebagai Bahan,” … e-Journal Pustaka Kesehat., vol. 8, no. 1, p. 48, 2020.

Aris Ma’ruf, Endang Safitri, Retna Yulrosly Ningtias, Fernanda Desmak Pertiwi, and Firman Rezaldi, “Antibakteri Gram Positif dan Gram Negatif dari Sediaan Sabun Cuci Piring Fermentasi Kombucha Bunga Telang (Clitoria ternatea L) sebagai Produk Bioteknologi Farmasi,” J. Kesehat. dan Kedokt., vol. 1, no. 2, pp. 16–25, 2022, doi: 10.56127/jukeke.v1i2.115.

A. Fitriani, Y. Hamdiyati, and R. Engriyani, “Aktivitas Antifungi Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) terhadap Pertumbuhan Jamur Candida albicans secara in vitro,” Biosfera, vol. 29, no. 2, pp. 71–79, 2012.

T. Rooban, G. Mishra, J. Elizabeth, K. Ranganathan, and T. R. Saraswathi, “Effect of habitual arecanut chewing on resting whole mouth salivary flow rate and pH.,” Indian J. Med. Sci., vol. 60, no. 3, pp. 95–105, Mar. 2006.

A. P. Aditama, M. Agil, and H. Laswati, “Aktivitas Antiosteoporosis Ekstrak Etanol 96 % Daun Abelmoschus manihot L. Medik Secara in Vitro Menggunakan Sel Preosteoblas MC3T3-E1,” Maj. Obat Tradis. (Traditional Med. Journal), vol. 21, no. 3, pp. 116–123, 2016.

A. Lukas, “Formulasi Obat Kumur Gambir dengan Tambahan Peppermint dan Minyak Cengkeh,” J. Din. Penelit. Ind., vol. 23, no. 2, p. 71, 2012.