Comparison of the Effectiveness of Giving Jicama Extract (Pachyrhizus Erosus) with Egg White in the Process of Healing Burns on the Backs of Wistar White Rats (Rattus Norvegicus)
Keywords:
Jicama Extract, Egg White, Healing Burns, Collagen Density, SkinAbstract
Burns are tissue damage caused by heat, chemicals, electricity, radiation, or the sun. The seriousness (degree) of the wound is based on the depth of the wound and the amount of skin affected. This condition can be painful and cause infection if not treated. For this reason, it is necessary to treat and treat burn wounds using various forms of medication to help the burn wound healing process. This study aims to determine whether a cream made from yam extract (Pachyrhizus Erosus) and egg white can speed up recovery from burn damage. In this study, we compared the efficacy of treating burns on the backs of white rats (Rattus norvegicus) of the Wistar strain using jicama (pochyrhizus erosus) extract vs. egg white using a pre-test, post-test, with control group design. This study tests the claim that jicama extract cream heals burn wounds better than egg white. When undertaking this research, it's crucial to consider other factors, such as extract concentration. Another factor affecting this study's results is the small sample size of 24 white mice. A large number of samples in a research study minimizes the chance of generalization errors. Stress can significantly affect wound healing in rats. Therefore, it must be considered as an internal factor. Stress in mice raises cortisol levels, suppressing cellular immunity and slowing wound healing.
References
Adha, A., Dewana, W., Suyono, T., Chiuman, L., & Ginting, S. F. (2022). Testing Antioxidant And Antibacterial Activity Of Andaliman Fruit ( Zanthoxylum Acanthopodium Dc .) Ethanol Extract With Abts Acid ) And Minimum Resistant Concentration. International Journal of Health and Pharmaceutical Testing, 2(1), 188–196.
Ahmed, M., Ji, M., Qin, P., Gu, Z., Liu, Y., Sikandar, A., … Javeed, A. (2019). Phytochemical screening, total phenolic and flavonoid contents and antioxidant activities of citrullus colocynthis L. and Cannabis Sativa L. Applied Ecology and Environmental Research, 17(3), 6961–6979. https://doi.org/10.15666/aeer/1703_69616979
Alamgir, A. N. M. (2018). Biotechnology, in vitro production of natural bioactive compounds, herbal preparation, and disease management (treatment and prevention). In Progress in Drug Research (Vol. 74). Springer International Publishing. https://doi.org/10.1007/978-3-319-92387-1_7
Andriana, N., Lister, I. N. E., Fachrial, E., Ginting, C. N., & Lie, S. (2020). Effectiveness Test of Wound Healing based Virgin Coconut Oil toward Commercial Products on Rabbits. MECnIT 2020 - International Conference on Mechanical, Electronics, Computer, and Industrial Technology, 104–107. https://doi.org/10.1109/MECnIT48290.2020.9166656
Andritoiu, C. V., Andriescu, C. E., Danu, M., Lungu, C., Ivanescu, B., Havarneanu, C., & Popa, M. (2021). Evaluation of the wound healing potential of some natural polymers on three experimental models. Pharmaceuticals, 14(5), 1–17. https://doi.org/10.3390/ph14050465
Asadi, S. Y., Parsaei, P., Karimi, M., Ezzati, S., Zamiri, A., Mohammadizadeh, F., & Rafieian-kopaei, M. (2013). Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat. International Journal of Surgery, 11(4), 332–337. https://doi.org/10.1016/j.ijsu.2013.02.014
Baquero, F., & Levin, B. R. (2021). Proximate and ultimate causes of the bactericidal action of antibiotics. Nature Reviews Microbiology, 19(2), 123–132. https://doi.org/10.1038/s41579-020-00443-1
Campbell, D. T., & Stanley, J. C. (2015). Experimental And Quasi-Experiment Designs for Research (Vol. 29). Wilmington, Massachusetts, U.S.A: Cengage Learning. https://doi.org/10.1037/022808
Coskun, O., Kanter, M., Korkmaz, A., & Oter, S. (2005). Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacological Research, 51(2), 117–123. https://doi.org/10.1016/j.phrs.2004.06.002
Enwemeka, C. S., Baker, T. L., & Bumah, V. V. (2021). The role of UV and blue light in photo-eradication of microorganisms: Photo-Eradication of Microorganisms. Journal of Photochemistry and Photobiology, 8, 100064. https://doi.org/10.1016/j.jpap.2021.100064
Erwiyani, A. R., Haswan, D., Agasi, A., & Karminingtyas, S. R. (2020). The Effect of Gel and Cream Dosage Forms of Moringa Leaves (Moringa oleifera Lamk) On The Reduction of Burns in Rats. Indonesian Journal of Pharmacy and Natural Product, 03(02), 41–52.
Ginting, C. N., Lister, I. N. E., Girsang, E., Riastawati, D., Kusuma, H. S. W., & Widowati, W. (2020). Antioxidant Activities of Ficus elastica Leaves Ethanol Extract and Its Compounds. Molecular and Cellular Biomedical Sciences, 4(1), 27. https://doi.org/10.21705/mcbs.v4i1.86
Grey, J. E., & Harding, K. G. (2009). ABC of Wound Healing (April, Vol. 332). Hoboken, New Jersey, USA: Blackwell Publishing.
Hendriati, L., Hamid, I. S., Widodo, T., Wandasari, C., & Rista, P. M. (2018). Efek Gel Putih Telur Terhadap Penyembuan Luka Bakar pada Tikus Putih (Rattus novergicus). Jurnal Ilmu Kefarmasian Indonesia, 16(2), 231–237.
Hendy, H., & Lister, I. N. E. (2019). Tingkat Efektivitas Penyembuhan Luka Bakar Derajat IIA dengan Pemberian Madu dan Pemberian Salep Nebacetin pada Tikus Putih (Rattus Norvegicus). Jurnal Kedokteran Dan Kesehatan, 15(2), 130. https://doi.org/10.24853/jkk.15.2.130-134
Ivanalee, A. S., Yudaniayanti, I. S., Yunita, M. N., Triakoso, N., Hamid, I. S., & Saputro, A. L. (2018). Efektivitas Sugar Dressing (100% Gula) dalam Meningkatkan Kepadatan Kolagen pada Proses Penyembuhan Luka Bakar Buatan pada Kulit Tikus Putih (Rattus norvegicus) Jantan. Jurnal Medik Veteriner, 1(3), 134. https://doi.org/10.20473/jmv.vol1.iss3.2018.134-141
Juleli, S., Amir, A., & Serudji, J. (2020). Uji Efektivitas Putih Telur Ayam Kampung ( Gallus domesticus ) Terhadap Penyembuhan Luka Bakar Derajat II. Jurnal Ilmu Kesehatan Indonesia, 1(2), 185–192.
Kurniawan, Pertiwi, A. T., & Lestari, I. T. (2021). Analisis Kadar Flavonoid Total Ekstrak Sirih Hijau (Piper betle L.). Journal of Islamic Pharmacy, 5(1), 80–85.
Latcuba, S. P., Chiuman, L., Nasution, A. N., & Ginting, C. N. (2022). Analysis of Wound Healing Activity from Rose Petal Extract Ointment in Wistar Rats. IOP Conference Series: Earth and Environmental Science, 1083(1). https://doi.org/10.1088/1755-1315/1083/1/012047
Li, W., & Li, N. (2020). Uji Sitotoksik dan Anti-Inflamasi Ekstrak Buah Bengkuang (Pachyrizus erosus (L.) Urb.) terhadap Sel RAW 264.7 yang Distimulasi Lipopolisakarida. E-Biomedik, 8(2), 187–195. Retrieved from https://ejournal.unsrat.ac.id/index.php/ebiomedik/article/view/31465
Lin, F., Bao, Y.-W., & Wu, F.-G. (2019). Carbon Dots for Sensing and Killing Microorganisms. Journal of Carbon Research, 5(2), 33. https://doi.org/10.3390/c5020033
Mawarni, E., Ginting, C. N., Chiuman, L., Girsang, E., Handayani, R. A. S., & Widowati, W. (2020). Antioxidant and Elastase Inhibitor Potential of Petals and Receptacle of Rose Flower (Rosa damascena). Pharmaceutical Sciences and Research, 7(2), 105–113. https://doi.org/10.7454/psr.v7i2.1016
Mulyaningsih, S., & Mufidah, S. (2021). the Effectiveness of Domestic Chicken Egg Whites in. Major Challenge and Trends in Pharmaceutical Science 2021, 158–169.
Notoatmodjo, S. (2018). Metodologi Penelitian Kesehatan (3rd ed.). Jakarta: Rineka Cipta.
Rahminiwati, M. (2020). Aktivitas Antimikroorganisme Ekstrak Etanol 70 % Biji Bengkuang Terhadap Staphylococcus epidermidis, Pseudomonas aeruginosa dan Candida Albican. Jurnal Sain Veteriner, 38(3), 289. https://doi.org/10.22146/jsv.44589
Rumpf, J., Burger, R., & Schulze, M. (2023). Statistical evaluation of DPPH, ABTS, FRAP, and Folin-Ciocalteu assays to assess the antioxidant capacity of lignins. International Journal of Biological Macromolecules, 233(February). https://doi.org/10.1016/j.ijbiomac.2023.123470
Salem, N., Helmi, N., & Assaf, N. (2018). Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity, 2018. https://doi.org/10.1155/2018/9658230
Shehabeldine, A. M., Amin, B. H., Hagras, F. A., Ramadan, A. A., Kamel, M. R., Ahmed, M. A., … Salem, S. S. (2023). Potential Antimicrobial and Antibiofilm Properties of Copper Oxide Nanoparticles: Time-Kill Kinetic Essay and Ultrastructure of Pathogenic Bacterial Cells. Applied Biochemistry and Biotechnology, 195(1), 467–485. https://doi.org/10.1007/s12010-022-04120-2
Sorg, H., Tilkorn, D. J., Hager, S., Hauser, J., & Mirastschijski, U. (2017). Skin Wound Healing: An Update on the Current Knowledge and Concepts. European Surgical Research, 58(1–2), 81–94. https://doi.org/10.1159/000454919
Sun, W., Chen, M., Duan, D., Liu, W., Cui, W., & Li, L. (2023). Effectiveness of moist dressings in wound healing after surgical suturing: A Bayesian network meta-analysis of randomised controlled trials. International Wound Journal, 20(1), 69–78. https://doi.org/10.1111/iwj.13839
Suwarno, B., & Nugroho, A. (2023). Kumpulan Variabel-Variabel Penelitian Manajemen Pemasaran (Definisi & Artikel Publikasi) (1st ed.). Bogor: Halaman Moeka Publishing.
Syaputri, I., Girsang, E., & Chiuman, L. (2022). Test Of Antioxidant And Antibacterial Activity Of Ethanol Extract Of Andaliman Fruit ( Zanthoxylum Acanthopodium Dc .) With Dpph ( 1 . 1-Diphenyl-2- Picrylhydrazil ) Trapping Method And Minimum Inhibitory Concentration. International Journal of Health and Pharmaceutical Test, 2(2), 215–224. https://doi.org/https://doi.org/10.51601/ijhp.v2i2.36
Zuhaira, S., Nizam, N. M., & Ridzuan, P. (2018). The Efficacy of Psidium guajava Linn Leaf Extractsfrom Selangor Region Against Gram-Positive and Gram-Negative Bacteria. Folia Medica Indonesiana, 54(4), 294–300. https://doi.org/10.20473/fmi.v54i4.10716
