Hs-CRP Levels In Adolescents With Obesity And Non-Obesity

Erni Murdaningsih; Aidah Juliaty

Authors

Erni Murdaningsih Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar, Indonesia
Aidah Juliaty Wahidin Sudirohusodo Hospital, Makassar, Indonesia

Keywords:

Adolescents, hs-CRP, Nutritional status, Obese

Abstract

Increased hs-CRP levels are a response to increased cytokine secretion in fat tissue in obese adolescents so that it can be used as a risk marker for disease. The study aims to determine the value of hs-CRP levels in obese and non-obese adolescents in middle and high schools in Makassar, South Sulawesi. The design of this research is analytical research with a cross-sectional design. The research sample was adolescents with obesity and non-obese in junior and senior schools in Makassar, South Sulawesi. Data were analyzed using the chi-square test, Mann-Whitney test, and ROC curve analysis. This research obtained 150 adolescents. The average hs-CRP level in obese adolescents was 10.60 mg/L. The average hs-CRP level in non-obese adolescents was 2.06 mg/L. From the statistical test results, it was found that the p-value (0.000) was <0.05, which means that there was a difference in mean hs-CRP between the obese and non-obese categories. The results of the ROC analysis obtained a cut-off of 6.53 mg/dl. The area under curve (AUC) value is 0.945 which is in the strong category in predicting the risk of cardiovascular disease in obese and non-obese adolescents. The sensitivity value is 93.48% and the specificity is 93.10%, hs-CRP ≥ 6.53 mg/dl can predict risk factors for cardiovascular disease in obese adolescents by 57.61% and predict non-risk factors in non-obese adolescents by 56.90%. hs-CRP levels can be a marker of cardiovascular disease in obese adolescents.

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