Comparison of the reduction in blood glucose levels of mice (mus musculus) given boiled water from ginger (zingiber officinale) with metformin

Ida Royani; Aining Rezkyana; Rezky Putri Indarwati Abdullah; Irmayanti Haidir Bima; Febie Irsandy Syahruddin

Authors

Ida Royani Departemen Ilmu Gizi Fakultas Kedokteran UMI
Aining Rezkyana Mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran UMI
Rezky Putri Indarwati Abdullah Departemen Ilmu Kesehatan Masyarakat Fakultas Kedokteran UMI
Irmayanti Haidir Bima Departemen Patologi Klinik Fakultas Kedokteran UMI
Febie Irsandy Syahruddin Departemen Radiologi Fakultas Kedokteran UMI

Keywords:

Water decoction of ginger, Fasting blood glucose, Mice

Abstract

Elevated blood sugar levels that exceed the established normal limits are a typical symptom of diabetes, a metabolic disorder. Traditional medicine is said to have fewer side effects than modern medicine, which has led to its long history of being favored by many people diagnosed with diabetes. People often use ginger as an herbal remedy for hypoglycemia. Ginger can be used as a natural antidiabetic drug due to the antiglycemic effect of its flavonoid content. To determine the comparison of blood glucose levels of mice (Mus musculus) given water decoction of ginger (Zingiber officinale) with metformin.Experimental research with pre and post test randomized controlled group design There was a decrease in the average blood glucose level of mice (Mus musculus) given water decoction of ginger (Zingiber officinale), from ±185.5 mg/dL to ±136.17 mg/dL, but not as good as metformin, which decreased from ±191 .17 mg/dL to ±108.67 mg/dL. Water decoction of ginger (Zingiber officinale) can reduce fasting blood glucose levels in mice (Mus musculus) although not as well as mice (Mus musculus) given metformin.

References

Kementrian Kesehatan Republik Indonesia. Tetap Produktif, Cegah Dan Atasi Diabetes Mellitus. Pusat Data dan Informasi Kementrian Kesehatan RI (2020).

Aprilia, N., Ariyani, A. D. & Hidayatin, N

. Pengaruh Rebusan Buncis Terhadap Kadar Gula Darah Pada Penderita Diabetes Melitus di Kelurahan Tukangkayu

Wilayah Kerja Puskesmas Sobo Banyuwangi. J. Kesehat. 11, 122–135 (2018).

Magliano, D. J. & Boyko, E. J. IDF Diabetes Atlas. (International Diabetes Federation, 2021). doi:10.1242/jeb.64.3.665.

Pertiwi, M., indahyani, didin & praharani, depi. Level Glukosa Darah pada Mencit Diabetes Setelah Pemberian Ekstrak Rumput Laut Coklat (Phaeophyta). e-Journal Pustaka Kesehat. 9, 84–89 (2021).

Gumantara, M. P. B. & Oktarlina, R. Z. Perbandingan Monoterapi dan Kombinasi Terapi Sulfonilurea-Metformin terhadap Pasien Diabetes Melitus Tipe 2. Majority 6, 55–59 (2017).

Wicaksono, A. P. Pengaruh Pemberian Ekstrak Jahe Merah (Zingiber Officinale) terhadap Kadar Glukosa Darah Puasa dan Postprandial pada Tikus Diabetes. Majority 4, 97–102 (2015).

Suharto, I. P. S., Lutfi, E. I. & Rahayu, M. D. Pengaruh Pemberian Jahe (Zingiber officinale) Terhadap Glukosa Darah Pasien Diabetes Mellitus. Care J. Ilm. Ilmu Kesehat. 7, 76 (2019).

Yanto, A. R., Mahmudati, N. & Susetyorini, E. Steeping of Ginger (Zingiber officinale Rosce) Lowers Blood Glucose in Rat Model Type-2 Diabetes (NIDDM) as a Learning Resource Biology. J. Pendidik. Biol. Indones. 2, 258–264 (2016).

Stevani, H. Praktikum Farmakologi. in Modul Bahan Ajar Cetak Farmasi 171 (Kementrian Kesehatan RI Pusat Pendidikan Sumber Daya Manusia Kesehatan Badan Pengembangan dan Pemberdayaan Sumber Daya Manusia Kesehatan, 2016).

Chougale, A. D., Panaskar, S. N., Gurao, P. M. & Arvindek, A. U. Optimization of Alloxan Dose is Essential to Induce Stable Diabetes for Prolonged Period. Asian J. Biochem. 2, 402–408 (2007).

Al-Amin, Z. M., Thomson, M., Al-Qattan, K. K., Peltonen-Shalaby, R. & Ali, M. Anti-diabetic and Hypolipidaemic Properties of Ginger ( Zingiber officinale) in Streptozotocin-induced Diabetic Rats. Br. J. Nutr. 96, 660–666 (2006).

Mahmudati, N. Wedang Jahe Berpotensi Menurunkan Risiko Diabetes Tipe 2 (Studi Pada Tikus Putih Betina Yang Diberi Diet Tinggi Lemak (Hfd)). Pros. Semin. Nas. from Basic Sci. to Compr. Educ. 2, 164–166 (2016).

Setiadi, E., Peniati, E. & Susanti, R. Pengaruh Ekstrak Kulit Lidah Buaya Terhadap Kadar Gula Darah Dan Gambaran Histopatologi Pankreas Tikus Yang Diinduksi Aloksan. 9, 171–185 (2020).

Yanti, E. D., Dewi, N. W. S. & Jawi, I. M. Kombinasi Ekstrak Sambiloto Dengan Metformin Lebih Baik Dalam Memperbaiki Sel Beta Pulau Langerhans Dari Pada Metformin. E-Jurnal Med. 8, (2019).

Alshathly, M. Efficacy of Ginger (Zingiber officinale) In Ameliorating Streptozotocin-induced Diabetic Liver Injury in Rats: Histological and Biochemical Studies. J. Microsc. Ultrastruct. 7, 91 (2019).

Simatupang, A. Monografi. Farmakologi klinik obat-obat Diabetes Mellitus Tipe 2. Book (FK UKI, 2019).

Sopianti, D. S., Nengsi, A. S. & Yanuarto, T. Gambaran Efek Samping Metformin Pada Pasien Diabetes Melitus Tipe II. 7, 209–221 (2020).

El-Seedi, H. R. et al. Plants mentioned in the Islamic Scriptures (Holy Qur’ân and Ahadith): Traditional uses and medicinal importance in contemporary times. Journal of Ethnopharmacology vol. 243 (2019).