Chemical And Physical Evaluation Of  Herbal Artificial Saliva Formulations-Scoping Review

Faisal kuswandani; Felisha Febriane Balafif; Nuroh Najmi; Anggun Rafisa

Authors

Faisal kuswandani Pharmacy, Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Indonesia
Felisha Febriane Balafif Microbiology, Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Indonesia https://orcid.org/0000-0003-4366-220X
Nuroh Najmi Anatomy Pathology, Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Indonesia https://orcid.org/0000-0001-7214-1310
Anggun Rafisa Physiology, Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Indonesia https://orcid.org/0000-0002-2960-4014

Keywords:

artificial saliva, herbal, chemical and physical, rheology

Abstract

Saliva plays an important role in physiological function. Alteration in saliva production results in serious health problems that affect patient oral health-related quality of life (OHRQiL). the purpose of the research was to investigate the chemical and physical evaluation of natural artificial saliva formulations. Methods, the data synthesis protocol for a rapid review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P). Electronic databases were searched on articles published in 2004- 2024. evaluating Chemical and physical properties of herbal artificial saliva formulations in preclinical study. Results, Identification from the Science Direct and PubMed databases obtained 332 scientific articles and 3 articles met inclusion criteria. Basella alba Linn. (Ceylon Spinach mucilage) shows non-Newtonian characteristic fluid, similar to normal human saliva. It has antioxidative activity, adhesion inhibition, and non-toxic. Propolis extract and Aloe vera extract showed minimal effect on viscoelastic properties but were still in the range of normal human saliva. Dioscorea batatas (Yam tuber mucilage) viscosity shows non-Newtonian characteristic fluid and antibacterial activity by influenced the enzymatic activity of lysozyme and peroxidase. Conclusion, Chemical and physiological evaluation shows that herbal plant extract has the potential to be used as an artificial saliva constituent. It had a viscosity in the range of normal human saliva with several advantages in terms of pharmacological activity.

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