Evaluation Of Side Effects Of First-Line Antiretroviral (ARV) Therapy In HIV Patients At Kassi-Kassi Public Health Center Of Makassar
Keywords:
Antiretroviral (ARV), HIV, Drug Side Effects, PatientsAbstract
The treatment for HIV/AIDS therapy is by administering antiretrovirals (ARVs) for life, therefore it is necessary to monitor patients for side effects or symptoms of ARV toxicity. The aim of this study is to evaluate the side effects of drugs in HIV sufferers who were taking first-line antiretroviral (ARV) drugs at the Kassi-Kassi Public Health Centre of Makassar. This research was quantitative research with descriptive research type. The results showed that of the 36 patients who met the inclusion and exclusion criteria based on their characteristics, the majority of respondents were male (91.67%), in the 25-54 year age group (72.22%), and had a tertiary level education ( 58.33%). Based on the length of time they received antiretroviral drug therapy (ARV), the majority of patients were in the 6 months-5 years category (80.56%), with the most widely used ARV combination being tenofovir + lamivudine + efavirenz (47.22%). The number of patients who did not experience ARV side effects was greater (50.7%) than those who experienced side effects. The most common side effects include:dizziness, nausea, rash, fatigue and sleep disturbances. Even though several patients experienced ARV side effects, judging from the medical records, after treatment of ARV side effects, the patients continued therapy well.
References
Z. Ma, L. Guo, M. Zhou, and H. Zuo, 'HIV/AIDS-related knowledge and attitudes towards HIV rapid testing among Chinese college students: Findings from a cross-sectional survey', vol. 36, no. September, 2023.
TA & MA Hapsari, 'The Practice of Antiretroviral Therapy in Children Suffering from HIV/AIDS',Higeia J. Public Heal. Res. Dev., vol. 1, no. 3, pp. 625–634, 2017.
S. Wahyuni, A. Zulkifli, Y. Thamrin, and AA Arsin, 'The effect of counseling on adherence to ARV therapy in HIV/AIDS patients in HA Sultan Daeng Radja Bulukumba Regency',Enferm. Clin., vol. 30, pp. 362–366, 2020.
Ministry of Health of the Republic of Indonesia, 'HIV AIDS Annual Report 2022', Jakarta, 2022.
MKR Indonesia, 'Decree of the Minister of Health of the Republic of Indonesia NumberHk.01.07/Menkes/90/2019 Concerning National Guidelines for HIV Management Medical Services', 2019.
H. Meriyani, NI Nyoman, W. Udayani, and KA Adrianta, 'Evaluation of Liver Function in HIV/AIDS Patients with ARV Therapy at Mangusada Regional Hospital',J. Ilm. Medicam., vol. 4, no. 2, pp. 2356–4818, 2018.
Jamie J Coleman; Sarah K Pontefract, 'Adverse Drug Reactions',C. Clin. Pharmacol., vol. 16, no. 5, pp. 481–5, 2016.
A. Jain, RJ Lihite, M. Lahkar, and SK Baruah, 'HIV & AIDS Review A study on adverse drug reactions to first-line antiretroviral therapy in HIV infected patients at a tertiary care hospital in Northeast India',HIV AIDS Rev., pp. 2–6, 2016.
Mitha Yunda Pertiwi, Indah Sapta Wardani, and AA Ayu Niti Wedayani, 'Profile of Side Effects of Using Antiretrovirals in Hiv/Aids Sufferers in Vct Polyclinics in Mataram City in 2019',Unram Med. J., vol. 9, no. 4, pp. 292–299, 2021.
E. Rampa, R. Prastyawati, and H. Sinaga, 'Examination of urea and creatinine levels in HIV patients receiving ARV therapy at the Harapan Sentani Community Health Center, Jayapura Regency, Papua',J. Researcher. Health. 'FORIKES VOICE' (Journal Heal. Res. 'Forikes Voice'), vol. 10, no. 3, p. 223, 2019.
T. Barus, 'Evaluation of Side Effects of Antiretroviral Drugs and Their Management in HIV/AIDS Patients at the Penjaringan District Health Center, North Jakarta for the 2013–2015 Period',Soc. Clin. Pharm. Indonesia. J., vol. 2, no. 1, pp. 29–37, 2017.
IO Putrinda, YP Sukmawan, and V.Nurviana, 'Proceedings of the National Seminar on Dissemination of Research Results from the Undergraduate Pharmacy Study Program on Evaluation of Drug Use and Side Effects in HIV/AIDS Sufferers in One of the Hospitals in Tasikmalaya City', vol. 2, 2022.
JW Corbett, A.H & Dana,DRUG INFORMATION HANDBOOK, 25TH EDITION. American: American Pharmacy Association., 2016.
National Institute Of Health, 'Side Effects of HIV Medicines', 2021. [Online]. Available: https://hivinfo.nih.gov/understanding-hiv/fact-sheets/hiv-medicines-and-side-effects.
DQN Salman, 'LITERATURE STUDY EVALUATION OF ANTIRETROVIRAL USE IN HIV/AIDS (ACQUIRED IMMUNE DEFICIENCY SYNDROME) PATIENTS',J. Ilm. Indonesia., vol. 7, no. 11, pp. 1–19, 2022.
Lusa Rochmawati and Ina Kuswanti, “Persepsi Kader Tentang Upaya Penanggulangan HIV/AIDS Dan Pencegahan Penularan HIV Dari Ibu Ke Anak”, INHEALTH, vol. 2, no. 1, p. 37~43, Feb. 2023
D. Puspasari, R. Wisaksana, and R. Ruslami, 'Overview of Side Effects and Compliance with Antiretroviral Therapy in HIV Patients at Dr Hospital. Hasan Sadikin Bandung 2015 in HIV Patients at Dr. Hasan Sadikin Hospital in 2015',Jsk, vol. 3, no. 4, pp. 175–181, 2018.