Literature Review: Curcumin Alternative Therapy For Breast Cancer
Keywords:
Curcumin, Breast Cancer, Alternative therapy, anticancerAbstract
Breast cancer is a serious disease that affects millions of people worldwide every year. Risk factors include gender, age, family history, and genetic factors. Although there are treatment methods such as surgery, radiation, and chemotherapy, breast cancer management often brings various physical, social, psychological, and financial problems for patients. Therefore, alternative treatments like the use of herbal plants, particularly compounds like curcumin, have been researched as potential anticancer agents with minimal side effects. The aim of this study is to explore in depth the potential of curcumin in breast cancer. This article is compiled from various databases, including Pubmed and Google Scholar, using the keywords "curcumin, breast cancer, anticancer." The journals sought were published between 2015 and 2024, and five journals were identified as relevant to the topic for further discussion. Based on literature studies, several mechanisms of curcumin against breast cancer include the regulation of protein signaling pathways, inhibition of cancer cell proliferation, induction of apoptosis, and reduction of drug resistance. Additionally, curcumin can also inhibit metastasis and increase the sensitivity of cancer cells to other therapies. The combination of curcumin with other drugs like tamoxifen can enhance its effectiveness in treating breast cancer. Based on this, it can be concluded that curcumin can be used as an alternative therapy for breast cancer through its various mechanisms.
References
Colacino, Justin A et al. 2016. “Transcriptomic Profiling of Curcumin Treated Human Breast Stem Cells Identifies a Role for Stearoyl Coa-Desaturase in Breast Cancer Prevention.” Departement Of Health & Human Services 349(1): 29–41.
Giordano, Antonio, and Giuseppina Tommonaro. 2019. “Curcumin and Cancer.” Nutrients 11(10).
Hosseini, Azar, and Ahmad Ghorbani. 2015. “Cancer Therapy with Phytochemicals: Evidence from Clinical Studies.” Avicenna journal of phytomedicine 5(2): 84–97. http://www.ncbi.nlm.nih.gov/pubmed/25949949%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4418057.
Laza-Vásquez, Celmira et al. 2022. “Views of Health Professionals on Risk-Based Breast Cancer Screening and Its Implementation in the Spanish National Health System: A Qualitative Discussion Group Study.” PLoS ONE 17(2 February): 1–22.
Liu, Yufei et al. 2017. “Curcumin Inhibits Growth of Human Breast Cancer Cells through Demethylation of DLC1 Promoter.” Molecular and Cellular Biochemistry 425(1–2): 47–58.
Mock, Charlotta, Brian Jordan, and Chelliah Selvam. 2016. “Recent Advances of Curcumin and Its Analogues in Breast Cancer Prevention and Treatment.” PMC 176(5): 139–48.
PULUNGAN, Rafiah Maharani, and Fathinah Ranggauni HARDY. 2020. “Edukasi ‘Sadari’ (Periksa Payudara Sendiri) Untuk Deteksi Dini Kanker Payudara Di Kelurahan Cipayung Kota Depok.” Diseminasi: Jurnal Pengabdian kepada Masyarakat 2(1): 47–52.
Roihatul Mutiah. 2015. “Evidence Based Kurkumin Dari Tanaman Kunyit (Curcuma Longa) Sebagai Terapi Kanker Pada Pengobatan Modern.” Jurnal Farma Sains 1(1): 28–41. https://ejournal.uin-malang.ac.id/index.php/jip/article/view/4178/5588.
Seyfried, Thomas N., and Leanne C. Huysentruyt. 2013. “On the Origin of Cancer Metastasis.” Critical Reviews in Oncogenesis 18(1–2): 43–73.
Sharifi-Rad, Javad et al. 2020. “Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.” Frontiers in Pharmacology 11(September): 1–23.
Sharma, Ricky A. et al. 2004. “Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance.” Clinical Cancer Research 10(20): 6847–54.
Sianipar, Erlia Anggrainy, Melva Louisa, and Septelia Inawati Wanandi. 2018. “Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara Terhadap Tamoksifen Melalui Penghambatan Ekspresi P-Glikoprotein Dan Breast Cancer Resistance Protein.” Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 4(1): 1–11.
Tagde, Priti et al. 2021. “The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders.” Molecules 26(23).
Vigyan Kendra, Krishi et al. 2018. “Medicinal Properties of Turmeric (Curcuma Longa L.): A Review.” ~ 1354 ~ International Journal of Chemical Studies 6(4): 1354–57.
Yu, Liang Liang et al. 2011. “Curcumin Reverses Chemoresistance of Human Gastric Cancer Cells by Downregulating the NF-ΚB Transcription Factor.” Oncology Reports 26(5): 1197–1203.
Zafrial, Rizki Muhammad, and Riezki Amalia. 2018. “Artikel Tinjauan : Anti Kanker Dari Tanaman Herbal.” Farmaka 16(1): 15–23.
Zoi, Vasiliki et al. 2021. “The Role of Curcumin in Cancer Treatment.” Biomedicines 9(9): 1–19.
