HIV Complications On Ears, Nose, Throat And Skin: Literature Review
Keywords:
HIV, complications, ear, nose, throat, skinAbstract
Human immunodeficiency virus (HIV) is an agent that can cause infection. HIV/AIDS can cause various complications that affect various parts of the body, including the skin, ears, nose and throat.This research is a Literature Review with a Narrative Review design. The type of data is data published from internationally accredited scientific journals.In total there are 8 studies published in the last 10 years (2012-2022) consisting of 1 prospective study, 5 cross sectional studies, and 2 case report studies. Human Immunodeficiency Virustargets CD4+ T lymphocyte helper cells, causing an extreme form of immune resistance with persistent depletion of CD4+ T lymphocyte helper cells. HIV infection that is left unchecked eventually develops into Acquired Immunodeficiency Syndrome (AIDS). At this stage, the immune system cannot prevent infection, resulting in the death of the individual due to opportunistic infections. Common ear, nose, throat and skin manifestations in HIV positive patients include oral candidiasis, enlarged lymph nodes, rhinosinusitis, allergic rhinitis, enlarged lymph nodes. clear neck, enlarged adenoids, chronic suppurative otitis media, suppurative hidradenitis, lesions on the head and neck, with the most common being rhinosinusitis. Patients with chronic HIV infection without AIDS can experience oropharyngeal candidiasis, recurrent vulvovaginal candidiasis, disseminated cutaneous herpes simplex. Skin manifestations such as seborrhoeic dermatitis, bacillary angiomatosis, varicella-zoster virus reactivation, and molluscum contagiosum infections are common and tend to be severe in HIV patients. The incidence of HIV infection continues to increase, and Indonesia is one of the Southeast Asian countries experiencing a high number of cases. In Indonesia, around 540,000 people live with HIV. The number of new HIV infections increased from approximately 21,511 in 2012 to 41,250 in 2016.
References
Hosain Pour, A., Salari, S., & Ghasemi Nejad Almani, P. (2018). Oropharyngeal candidiasis in HIV/AIDS patients and non-HIV subjects in the Southeast of Iran. Current medical mycology, 4(4), 1–6. https://doi.org/10.18502/cmm.4.4.379
Opoku-Buabeng, J., & Dompreh, A. (2012). Ear, nose and throat lesions in hiv/aids patients in komfo anokye teaching hospital, kumasi, ghana. Journal of the West African College of Surgeons, 2(2), 27–39.
Swinkels HM, Justiz Vaillant AA, Nguyen AD, et al. HIV and AIDS. [Updated 2024 May 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534860/
van Heuvel Y, Schatz S, Rosengarten JF, Stitz J. Infectious RNA: Human Immunodeficiency Virus (HIV) Biology, Therapeutic Intervention, and the Quest for a Vaccine. Toxins (Basel). 2022 Feb 14;14(2)
Xu Y, Ollerton MT, Connick E. Follicular T-cell subsets in HIV infection: recent advances in pathogenesis research. Curr Opin HIV AIDS. 2019 Mar;14(2):71-76. [PMC free article] [PubMed]
Teeraananchai S, Kerr SJ, Amin J, Ruxrungtham K, Law MG. Life expectancy of HIV-positive people after starting combination antiretroviral therapy: a meta-analysis. HIV Med. 2017 Apr;18(4):256-266. [PubMed]
Kelley CF, Kitchen CM, Hunt PW, Rodriguez B, Hecht FM, Kitahata M, Crane HM, Willig J, Mugavero M, Saag M, Martin JN, Deeks SG. Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clin Infect Dis. 2009 Mar 15;48(6):787-94. [PMC free article] [PubMed]
Greub G, Ledergerber B, Battegay M, Grob P, Perrin L, Furrer H, Burgisser P, Erb P, Boggian K, Piffaretti JC, Hirschel B, Janin P, Francioli P, Flepp M, Telenti A. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet. 2000 Nov 25;356(9244):1800-5. [PubMed]
Sax PE, Erlandson KM, Lake JE, Mccomsey GA, Orkin C, Esser S, Brown TT, Rockstroh JK, Wei X, Carter CC, Zhong L, Brainard DM, Melbourne K, Das M, Stellbrink HJ, Post FA, Waters L, Koethe JR. Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials. Clin Infect Dis. 2020 Sep 12;71(6):1379-1389. [PMC free article] [PubMed]
Diaz RS, Hunter JR, Camargo M, Dias D, Galinskas J, Nassar I, de Lima IB, Caldeira DB, Sucupira MC, Schechter M. Dolutegravir-associated resistance mutations after first-line treatment failure in Brazil. BMC Infect Dis. 2023 May 24;23(1):347. [PMC free article] [PubMed]
DeKoven S, Naccarato M, Brumme CJ, Tan DHS. Treatment-emergent reverse transcriptase resistance during antiretroviral therapy with bictegravir, tenofovir alafenamide, and emtricitabine: A case series. HIV Med. 2023 Nov;24(11):1137-1143. [PubMed]
Wensing AM, Calvez V, Ceccherini-Silberstein F, Charpentier C, Günthard HF, Paredes R, Shafer RW, Richman DD. 2022 update of the drug resistance mutations in HIV-1. Top Antivir Med. 2022 Oct;30(4):559-574. [PMC free article] [PubMed]
Sutrasno MA, Yulia N, Rumana NA, Fannya P. Literature review gambaran karakteristik pasien HIV/AIDS di fasilitas pelayanan kesehatan di Indonesia. Jurnal Manajemen Informasi dan Administrasi Kesehatan. (2022) 5:56–65. [Google Scholar]
Januraga PP, Reekie J, Lestari BW, Iskandar S, Kusmayanti NA, Subronto YW, et al.. The cascade of HIV care among key populations in Indonesia: a prospective cohort study. Lancet HIV. (2018) 5:e560–8. doi: 10.1016/S2352-3018(18)30148-6, PMID: [PubMed] [CrossRef] [Google Scholar] [Ref list]
Ibrahim, Saif & Al-Saffar, Farah & Regenhardt, Robert & Guzman, Nilmarie. (2014). Pott’s Puffy Tumor: A New Complication of HIV. Journal of General Practice. 2. 10.4172/2329-9126.1000154.
Sebothoma, Ben PhD; Khoza-Shangase, Katijah PhD. Middle Ear Pathologies Persist in Adults Living With HIV Despite the Use of Antiretroviral Therapy. The Hearing Journal 75(12):p 30,31, December 2022. | DOI: 10.1097/01.HJ.0000904476.04752.51
Chao, C. K., Czechowicz, J. A., Messner, A. H., Alarcón, J., Kolevic Roca, L., Larragán Rodriguez, M. M., Gutiérrez Villafuerte, C., Montano, S. M., & Zunt, J. R. (2012). High prevalence of hearing impairment in HIV-infected Peruvian children. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 146(2), 259–265. https://doi.org/10.1177/0194599811429271
Shija, P. S., Karaba, J. A., Philemon, R. N., Minja, B. L., Mtenga, P. P., & Katundu, D. R. (2020). Prevalence of Ear Nose and Throat (ENT) Manifestations Among HIV Seropositive Patients at a Tertiary Hospital in Northern Tanzania: A Descriptive Cross-Sectional Study. HIV/AIDS (Auckland, N.Z.), 12, 425–429. https://doi.org/10.2147/HIV.S260908
Athanase, Masele & Singh, Karpal & Kalyanyama, Boniphace & Owibingire, Sira & Simon, Elison. (2020). Head and neck lesions among HIV/AIDS patients on highly active antiretroviral therapy attending the Muhimbili National Hospital in Dar es Salaam, Tanzania. Frontiers of Oral and Maxillofacial Medicine. 2. 2-2. 10.21037/fomm.2019.12.01.
Rankin, B. D., & Haber, R. M. (2021). Case report of hidradenitis suppurativa localized to the face in an HIV patient. SAGE open medical case reports, 9, 2050313X211057923. https://doi.org/10.1177/2050313X211057923
