Clinicopathologic Features Of Langerhans Cell Histiocytosis At Hasan Sadikin Hospital In 2010-2020
Keywords:
Clinicopathologic, Histopathologically, Langerhans Cell Histiocytosis, OrgansAbstract
Langerhans Cell Histiocytosis (LCH) is a rare neoplasm of myeloid origin, characterized by the proliferation of Langerhans cells expressing CD1a and CD207. While primarily affecting children, LCH can also occur in adults, though the incidence is extremely low. The disease manifests in various clinical forms, often complicating diagnosis and management. This study aims to describe the clinicopathological aspects of LCH cases treated at Hasan Sadikin Hospital (RSHS) Bandung over a ten-year period, from 2010 to 2020. Clinicopathological data of patients diagnosed with LCH at the Anatomical Pathology Department of Hasan Sadikin Hospital from 2010 to 2020 were retrospectively reviewed. Data collected included patient age, gender, anatomical location of the disease, and sampling methods used for diagnosis. Diagnosis of LCH was confirmed through morphological assessment of histopathologic specimens and fine needle aspiration biopsy (FNAB) smears. LCH remains a rare entity characterized by the abnormal proliferation of Langerhans cells, predominantly affecting children and most frequently involving the head region. Typical cytologic and histopathologic features are usually present, aiding in the diagnosis. However, variability in presentation underscores the importance of integrating clinical, radiologic, and immunohistochemical data for accurate diagnosis. Further research is warranted to explore long-term outcomes and optimal management strategies, particularly in regions with limited case data.
References
Chandekar, S.A., Shah, V.B. and Kavishwar, V. (2013) ‘Cytological diagnosis of Langerhans cell histiocytosis with cutaneous involvement’, Journal of Cytology, 30(1). Available at: https://journals.lww.com/jocy/fulltext/2013/30010/cytological_diagnosis_of_langerhans_cell.21.aspx.
St. Claire, K. et al. (2020) ‘Langerhans cell histiocytosis: A great imitator’, Clinics in Dermatology, 38(2), pp. 223–234. Available at: https://doi.org/https://doi.org/10.1016/j.clindermatol.2019.10.007.
Gong, L. et al. (2010) ‘Clonal Status and Clinicopathological Features of Langerhans Cell Histiocytosis’, Journal of International Medical Research, 38(3), pp. 1099–1105. Available at: https://doi.org/10.1177/147323001003800338.
Handa, U. et al. (2015) ‘Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration’, Journal of Cytology, 32(4), pp. 244–247. Available at: https://doi.org/10.4103/0970-9371.171237.
Hang, J.-F., Siddiqui, M.T. and Ali, S.Z. (2017) ‘Fine Needle Aspiration of Langerhans Cell Histiocytosis: A Cytopathologic Study of 37 Cases’, Acta Cytologica, 61(2), pp. 96–102. Available at: https://doi.org/10.1159/000468505.
Harmon, C.M. and Brown, N. (2015) ‘Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update’, Archives of Pathology & Laboratory Medicine, 139(10), pp. 1211–1214. Available at: https://doi.org/10.5858/arpa.2015-0199-RA.
Kumar, N., Sayed, S. and Vinayak, S. (2011) ‘Diagnosis of Langerhans Cell Histiocytosis on Fine Needle Aspiration Cytology: A Case Report and Review of the Cytology Literature’, Pathology Research International, 2011(1), p. 439518. Available at: https://doi.org/https://doi.org/10.4061/2011/439518.
Luciana, L. and Rusyati, L.M. (2016) ‘Histiositosis sel langerhans pada seorang anak’, Medicina, 47(2).
Lurdes, L. and Ariawati, K. (2017) ‘Cholestasis as manifestation of langerhans cell histiocytosis in an 18-months-old boy’, Medicina, 48(2), pp. 133–137. Available at: https://doi.org/10.15562/medicina.v48i2.42.
Morimoto, A. et al. (2014) ‘Recent advances in Langerhans cell histiocytosis’, Pediatrics International, 56(4), pp. 451–461. Available at: https://doi.org/https://doi.org/10.1111/ped.12380.
Oza, N. et al. (2015) ‘Cytological Diagnostic Approach in 3 Cases of Langerhans Cell Histiocytosis Presenting Primarily as a Thyroid Mass’, Acta Cytologica, 59(5), pp. 418–424. Available at: https://doi.org/10.1159/000440969.
Punia, R.S. et al. (2006) ‘Langerhans cell histiocytosis of skin: a clinicopathologic analysis of five cases’, Indian Journal of Dermatology, Venereology and Leprology, 72, p. 211. Available at: https://doi.org/10.4103/0378-6323.25782.
Safa Al Shaikh, M.D. et al. (2017) ‘Langerhans cell histiocytosis on fine needle aspiration cytology’, Bahrain Medical Bulletin, 39(3).
Satter, E.K. and High, W.A. (2008) ‘Langerhans cell histiocytosis: a case report and summary of the current recommendations of the Histiocyte Society’, Dermatology Online Journal, 14(3). Available at: https://doi.org/10.5070/D317b778j6.
Shi, S. et al. (2014) ‘Multifocal Langerhans cell histiocytosis in an adult with a pathological fracture of the mandible and spontaneous malunion: A case report’, Oncology Letters, 8(3), pp. 1075–1079. Available at: https://doi.org/10.3892/ol.2014.2272.
Sun, W.-G., Zhong, L.-S. and Chen, H. (2016) ‘A case of adult generalized cutaneous langerhans cell histiocytosis’, Annals of Dermatology, 28(2), p. 262.
Tian, Z. (2020) ‘Oral and Maxillofacial Langerhans Cell Histiocytosis: A Rare Case Report and Literature Review’, Clinics in Surgery, 5, p. 2730.
Yağcı, B. et al. (2008) ‘Langerhans Cell Histiocytosis: Retrospective Analysis of 217 Cases in a Single Center’, Pediatric Hematology and Oncology, 25(5), pp. 399–408. Available at: https://doi.org/10.1080/08880010802107356.
