Connection Inspection Blood Routine With Status History of Malaria at Ibnu Sina Hospital Makassar 2019-2024
Keywords:
Hemoglobin, Platelets, Leukocytes, malaria history statusAbstract
Malaria remains serious health problems in Indonesia, especially in the eastern region which has a high incidence . Routine blood tests are used to identify hematological abnormalities in malaria patients and the status of malaria history which is suspected to have a role in hematological changes , this is not fully understood . Therefore , it is necessary to explore the effect malaria history status on routine blood test results . To analyze the relationship between routine blood test results (hemoglobin, platelets , leukocytes ) and malaria history status in patients at Ibnu Sina Hospital Makassar during the period 2019-2024. Observational analytical design with a cross-sectional approaches . There were 43 patients diagnosed with malaria. Data were analyzed using the chi-square statistical test . The majority of malaria patients were aged 21-30 years and were dominated by man while the most common type of plasmodium was P. vivax and occurred in patients without a previous history of malaria. Routine blood results found that most Patients had normal hemoglobin (76.70%), thrombocytopenia (83.70%), and normal leukocytes levels (72.10%). These results indicate a significant relationship between malaria history and hemoglobin levels (p = 0.020) and platelet count (p = 0.010) because malaria patients who have a history of malaria already have partial immunity that can minimize the occurrence of hematological disorders . However , in leukocytes , there was no significant relationship between malaria history and leukocyte count (p = 0.503). A significant relationship was found between hemoglobin and platelets with malaria history status .
References
Al-Awadhi M, Ahmad S, Iqbal J. Current status and the epidemiology of malaria in the middle east region and beyond. Vol. 9, Microorganisms. MDPI AG; 2021. pp. 1–20.
Munro BA, McMorran BJ. Antimalarial Drug Strategies to Target Plasmodium Gametocytes. Parasitology. 2022 May 6; 2(2):101–24.
Ministry of Health of the Republic of Indonesia. Malaria is the World's Highest Cause [Internet]. 2023. Available from: https://www.malaria.id/profil
Emily Buck, Nancy A, Finnigan. Malaria - StatPearls - NCBI Bookshelf. 2023.
World Health Organization (WHO). Malaria [Internet]. 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/malaria
Shamim Jairajpuri Z, Jaseem Hassan M, Nabi F, Jetley Zeeba Shamin Jairajpuri S, Rana S, Jetley S. An Analysis of Hematological Parameters as a Diagnostic test for Malaria in Patients with Acute Febrile Illness: An Institutional Experience. Oman Medical Specialty Board Original Articles Oman Medical Journal. 2014; 29(1):12–7.
White NJ. Anaemia and malaria. Malar J. 2018 Oct 19; 17(1).
Artavanis-Tsakonas K, Tongren JE, Riley EM. The war between the malaria parasite and the immune system: Immunity, immunoregulation and immunopathology. Vol. 133, Clinical and Experimental Immunology. 2003. pp. 145–52.
Mayasari R, Andriayani D, Sitorus H, R&D LP, Jl Jend Yani Kemelek km BA, OKU Sumatra- South B, et al. Risk Factors Associated with Malaria Incidence in Indonesia (Riskesdas Further Analysis 2013). 2013.
solikhah. Pattern of malaria spread in Kokap District, Kulon Progo Regency, DIY. 2009; 15:213–22.
Trojánek M, Grebenyuk V, Richterová L, Zicklerová I, Nohýnková E, Manďáková Z, et al. Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic. Malar J. 2022 Dec 1; 21(1).
Autino B, Noris A, Russo R, Castelli F. Epidemiology of malaria in endemic areas. Mediterr J Hematol Infect Dis. 2012; 4(1).
Umi Kustiah S, Reza M. Hematological Profile Based on Plasmodium Type in Malaria Patients in Several Hospitals in Padang City. Andalas Health Journal [Internet]. 2020;9. Available from: http://jurnal.fk.unand.ac.id
López C, Yepes-Pérez Y, Hincapié-Escobar N, Díaz-Arévalo D, Patarroyo MA. What is known about the immune response induced by Plasmodium vivax malaria vaccine candidates? Vol. 8, Frontiers in Immunology. Frontiers Research Foundation; 2017.
John F. Fisher. Susceptibility to malaria: Genetic and environmental factors. 2021;
Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Jung RK, Nandy A, et al. Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites.
Journal of Infectious Diseases. 2007 Apr 1; 195(7):927–33.
Salsabila A, Gunawan CA, Irawiraman H. Hematological Profile of Inpatient Malaria Patients at Panglima Sebaya Hospital, Paser Regency for the Period of January 2015-March 2018. Journal of Science and Health. 2021 Aug 31; 3(4):551–7.
Blumenreich MS. he White Blood Cell and Differential Count. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Chapter 153.
White NJ. Severe malaria. Malar J. 2022 Dec 1; 21(1).
Starck T, Bulstra CA, Tinto H, Rouamba T, Sie A, Jaenisch T, et al. The effect of malaria on haemoglobin concentrations: a nationally representative household fixed-effects study of 17,599 children under 5 years of age in Burkina Faso. Malar J. 2021 Dec 1; 20(1).
Kathryn E, Webert D. Platelets in Thrombotic and Non-Thrombotic DIsordrs. Immune- mediated thrombocytopenia. 2010. pp. 542–555.
Asare R, Opoku-Okrah C, Danquah KO, Opare-Sem O, Addai-Mensah O, Gyamfi D, et al. Assessment of platelet index and marker of platelet activation in children with Plasmodium falciparum malaria. 2020;
Joseph M. Platelets and Parasites (Chapter 53) – Platelets in Thrombotic and Non-Thrombotic Disorders. 2010. pp. 815–823.
