Anti-Inflammatory Activity Test of Ointment Preparations of Nutmeg Leaf Extract from Fak-Fak (Myristica argentea Warb) Against Burns in Male Wistar White Rats

Maria Gloria Yeuyanan; Ratih Arum Astuti; A.M. Muslihin

Authors

Maria Gloria Yeuyanan Universitas Pendidikan Muhammadiyah Sorong
Ratih Arum Astuti University of Education Muhammadiyah Sorong
A.M. Muslihin University of Education Muhammadiyah Sorong

Keywords:

Fak-fak Nutmeg, Ointment Preparation, Anti-Inflammatory, Burn wounds.

Abstract

The fak-fak nutmeg plant (Myristica argentea Warb) is one type of spice plant native to Indonesia originating from fak-fak City. This nutmeg is included in the Myristicaceae family which can have secondary metabolite compounds in the form of alkaloids, tannins, flavonoids, saponins, and phenolics which have biological activity as an anti-inflammatory burn. This study aims to determine the anti-inflammatory activity and concentration of effective preparations. This study used test animals consisting of 15 male white rats which were divided into 5 groups, namely group I negative control (ointment base), group II positive control (bioplacenton) group III ointment extract of nutmeg leaves from fak-fak concentration 2%, group IV ointment extract of nutmeg leaves from fak-fak concentration 6% and group V ointment extract of nutmeg leaves from fak-fak concentration 10%. From the results of the research that has been done, the ointment preparation with 2% extract concentration shows inflammation healing activity against rats with wound shrinkage (0.676), ointment with 6% extract concentration (0.374) and for ointment with 10% extract concentration (0.313) while in the positive group shows inflammation healing activity with wound shrinkage (0.508) and negative group (0.755). From the results obtained, it can be concluded that the ointment preparation of nutmeg leaf extract from fak-fak (Myristica argentea Warb) is effective in healing inflammation, the most effective ointment preparation is an ointment preparation with 10% extract concentration.

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