The Role of Mitochondria in Aging and Modern Anti-Aging Therapeutic Approaches

Teguh Tanuwidjaja

Authors

Teguh Tanuwidjaja Master's Program in Skin Aging and Aesthetics, Faculty of Medicine, General Achmad Yani University

Keywords:

Mitochondria, Aging, Oxidative Stress, Mitochondrial Biogenesis, Anti-Aging Therapy

Abstract

Aging is a complex biological process characterized by a progressive decline in cellular and tissue function, ultimately affecting homeostasis and the overall health of the organism. One of the main mechanisms involved in the aging process is mitochondrial dysfunction, the energy-producing organelles that also play a crucial role in regulating oxidative stress, apoptosis, and cellular metabolism. This study aims to analyze the role of mitochondria in the aging mechanism and review various modern anti-aging therapeutic approaches that focus on restoring mitochondrial function. The research method used was a literature review, reviewing the latest scientific literature on mitochondrial biology, cellular aging processes, and potential therapies such as the use of mitochondrial antioxidants. The results indicate that mitochondria play a crucial role in the aging process through oxidative stress and mitochondrial DNA (mtDNA) damage, which leads to decreased energy production and cellular dysfunction. When the number of free radicals increases and mitochondrial repair capacity decreases, cells become vulnerable to damage that triggers aging and degenerative diseases such as Alzheimer's and Parkinson's. Various modern therapeutic efforts have been shown to improve this condition, including the use of mitochondria-targeted antioxidants (MitoQ), mitochondrial biogenesis-stimulating compounds (methylene blue), and SIRT1 activation to enhance cell defense. Lifestyle approaches such as regular exercise and a healthy diet also support mitochondrial function, while mitochondrial transplantation in animal studies has shown promising results in improving energy and slowing aging.

References

Astuti, R., Umboh, M. J., Pradana, A. A., Silaswati, S., Susanti, F., Resna, R. W., ... & Rekawati, E. (2023). Keperawatan Gerontik. PT. Sonpedia Publishing Indonesia.

Balaban, R. S., Nemoto, S., & Finkel, T. (2005). Mitochondria, oxidants, and aging. cell, 120(4), 483-495.

Fijri, S., Gustia, E., Dewi, O. T., & Marianti, L. (2022). Indonesia Penyakit Degeneratif Pada Lansia: Pencegahan Dan Penanganannya: Degenerative Diseases in the Elderly: Prevention and Treatment. CONS-IEDU, 2(2), 99-117.

Gomes, A. P., Price, N. L., Ling, A. J., Moslehi, J. J., Montgomery, M. K., Rajman, L., ... & Sinclair, D. A. (2013). Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), 1624-1638.

Irianti, T. T., & Pramono, S. (2022). Penuaan dan pencegahannya: Proses faali biokimiawi dan molekuler. Ugm Press.

Isrul, M., Adnan, A., & Islamia, M. N. (2025). Eksplorasi Berbagai Fungsi Mitokondria Melalui Pendekatan Meta-Analisis dalam Biologi Seluler. Spizaetus: Jurnal Biologi dan Pendidikan Biologi, 6(2), 301-311.

Kaeberlein, M. (2018). How healthy is the healthspan concept?. Geroscience, 40(4), 361-364.

Layal, K. (2016). Peran Nrf2 dalam patogenesis stres oksidatif dan inflamasi pada penyakit ginjal kronik. Syifa'MEDIKA: Jurnal Kedokteran dan Kesehatan, 7(1), 16-24.

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.

Maretha, D. E. (2019, August). Biogenesis Mitokondria. In Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sriwijaya (Vol. 1, No. 1, pp. 292-302).

Saras, T. (2023). Antioksidan: keajaiban molekul pelindung tubuh. Tiram Media.

Sari, W. P., Gaya, M. L., Irianto, G., & Karima, N. (2019). Managemen Topikal Anti-Aging pada Kulit. Medical Profession Journal of Lampung, 9(2), 228-234.

Sayuti, I. K., & Yenrina, I. R. (2015). Antioksidan. APPTI, Padang.

Situmorang, N., & Zulham, Z. (2020). Malondialdehyde (mda)(zat oksidan yang mempercepat proses penuaan). Jurnal Keperawatan Dan Fisioterapi (JKF), 2(2), 117-123.

Sugiyono, P. D. (2012). Metode Penelitian Tindakan (Pendekatan Kuantitatif, Kualitatif, dan R&D). Bandung: Remaja Rosdakarya.

Utami, S. (2009). Etiologi infertilitas pada pria akibat dari mutasi DNA mitokondria (mtDNA). Maranatha Journal of Medicine and Health, 9(1), 150489.

Yuslianti, E. R. (2018). Pengantar radikal bebas dan antioksidan. Deepublish.