Host Determinants on Death of Covid-19 Patients

Authors

  • Andi Nailah Amirullah Sekolah Tinggi Ilmu Kesehatan Yapika Makassar
  • Salki Sasmita Sekolah Tinggi Ilmu Kesehatan Yapika Makassar
  • Dewi Rizki Nurmala Hospital Research and Development Unit. Wahidin Sudirohusodo Makassar

Keywords:

Fasttrack, Determinant, Host, Death, Patient, Covid-19

Abstract

The 2019 corona virus infection (COVID-19) pandemic is a problem that is being faced in more than 200 countries in the world. The number of deaths from COVID-19 also increased to 33,673 in the world. The number of positive cases of COVID-19 worldwide has reached 1,936,700 people. Comorbid hypertension and diabetes mellitus, male gender, and active smoking are risk factors for SARS-Cov-2 infection.

The purpose of this study was to determine the host determinants (age, sex and comorbidities) in the death of Covid-19 patients in the hospital. Wahidin Sudirohusoso, Makassar City. This study uses a quantitative approach with a case control research design using secondary data sources from medical record data. Data analysis was carried out by univariate, bivariate, and multivariate analysis. The population in this study were all Covid-19 patients diagnosed and receiving treatment at RSUP Dr. Wahidin Sudirohusodo. The minimum required sample size for each case-control group is 68, with a ratio of 1:1. The results of the OR calculation showed that respondents aged 46 years had 5,958 times more deaths due to Covid-19 compared to the age group <46 years (95% CI 2,817-12,6042,817-12,604). The results of the Chi Square test show that there is no significant relationship between gender and the death of Covid-19 patients (P Value 0.195), so that respondents with male sex do not necessarily experience death from Covid-19 compared to female sex. The results of the OR calculation show that respondents who have comorbidities are 38,400 times more likely to die from Covid-19 than respondents who do not have comorbidities (95% CI 38,400 (12,319-119,694)). The variable that was significantly related to the death of Covid-19 patients was comorbidity with an OR of 3.648, meaning that Covid-19 patients with comorbidities had 3. There is a significant relationship between age and comorbidities with the death of Covid-19 patients and there is no significant relationship between gender and the death of Covid-19 patients. The results of the multivariate analysis showed that the variable that was significantly related to the death of Covid-19 patients was comorbid with an OR of 3.648. The active role of health workers is to carry out the socialization of Covid-19 prevention, so that it is hoped that the community will be able to take preventive measures and can reduce the death rate due to Covid-19.

References

Susilo, A., Coronavirus Disease 2019: Tinjauan Literature Terkini. Jurnal Penyakit Dalam Indonesia., 2020.

World Health Organization., https://covid19.who.int/. 2020.

World Health Organization., Coronavirus Disease 2019 (COVID-19) Situation Report-70. https:www.who.int/docs.default-source/coronaviruse/situation-reports/20200330-sitrep-70-covid-19.pdf?sfvrsn=7e0fe3f8_2, 2020.

Kementerian Kesehatan., 2020.

Kementerian Kesehatan., 2021. https://covid19.go.id/artikel/2022/01/21/keputusan-menteri-kesehatan-republik-indonesia-nomor-hk0107menkes64242021.

World Health Organization., 2021.

Grasselli, G., Greco, M., Zanella, A., Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units In lombardy, Italy. JAMA Intern Med, 2020. 180(10);1545-1546.

Cai, H., Sex difference and smoking predisposition in patients with COVID-19. Lancet Respir Med, 2020. published online March 11. DOI: 10.1016/S2213-2600(20)30076-X.

ECDC. Risk Factors adn Risk Groups Europe Central Disease Prevention Control. https:// https://www.ecdc.europa.eu/en/covid-19/latest-evidence/epidemiology. 2020.

Ho FK, Petermann-Rocha F, Gray SR, Jani BD, Katikireddi SV, Niedzwiedz CL, et al., Is Older Age Associated With COVID-19 Mortality In The Absence Of Other Risk Factors? General population cohort study of 470,034 participants. PLoS ONE 15(11): e0241824. https://doi.org/ 10.1371/journal 2020.

Biswas M, R.S., Biswas, TK, et al, Association of Sex, Age, and Comorbidities with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis. Intervirology 2021;64:36–47. https://doi.org/10.1159/000512592, 2020.

Suharjo B, U., M.S.Y., K-Means Cluster Analysis of Sex, Age, and Comorbidities in the Mortalities of Covid-19 Patients of Indonesian Navy Personnel. Jurnal Informatika dan Sains 1(4). https://trilogi.ac.id/journal/ks/index.php/JISA/oai. e-ISSN: 2614-8404, p-ISSN: 2776-3234, 2021.

Daud LM, N.E., Ratag TB, Hubungan Antara Umur Dan Jenis Kelamin Dengan Kejadian Coronavirus Disease-19 Di Kota Bitung Tahun 2020. Jurnal KESMAS: 1(11). 190-195. https://ejournal.unsrat.ac.id/, 2022.

Putri, N.A., Putra, E. A., dan Mariko, R, Hubungan Usia, Jenis Kelamin dan Gejala dengan Kejadian COVID-19 di Sumatera Barat. Majalah Kedokteran Andalas, 2021. 44 (2): p. 104–111.

Peckham, H., et al, Male Sex Identified by Global COVID-19 Meta-Analysis as A Risk Factor For Death and ITU Admission. Nature Communications, 2020. 11(1): p. 1-10.

Acharya, D., Lee, K., Lee, D., Lee, Y. and Moon, S. , Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes. Healthcare, 2020. 8(3): p. 338.

Corona, G., Pizzocaro, A., Vena, W., Rastrelli, G., Semeraro, F., Isidori, A., Pivonello,R., Salonia, A., Sforza, A. and Maggi, M, Diabetes is Most Important Cause for Mortality in COVID-19 Hospitalized Patients: Systematic Review and Meta-Analysis. Reviews in Endocrine and Metabolic Disorders, 2021. 22(2): p. 275- 296.

Vaikasuvu, R., et al, A Pooled Analysis Related to Disease Severity and Mortality. . Primary Care Diabetes. DOI : 10.1016/j.pcd.2020.08.015, 2021. 15(1).

Adinagoro RM , W.B., et al, Mortalitas Pasien COVID-19 dengan Komorbiditas Diabetes Mellitus. Anatomica Medical Journal. Fakultas Kedokteran (FK) Universitas Muhammadiyah Sumatera Utara (UMSU). http://jurnal.umsu.ac.id/index.php/AMJ, 2021. 40(3).

Putra AAMI, F., Hubungan Komorbiditas Terhadap Derajat Keparahan Admisi dan Outcome Pasien Covid-19. JHPSM Journal of Health Promotion and Service Management. DOI: https://doi.org/10.52232/jhpsm.v1i1.57. ISSN 2830-2729 EISSN 2830-5981, 2022. 1(1).

Khedr, E., Daef, E., Mohamed-Huseein, A, et al, Impact of Comorbidities on Covid-19 Outcome. medRvxiv. https://doi.org/10.1101/2020.11.28.20240267, 2020.

Wei-jie G., l.W., Zhao Y, et al, Comorbidity and Its Impact on 1590 Patients with COVID-19 in China. European Respiratory Journal. doi: 10.1183/13993003.00547-2020. 55(5:2000547).

Huang I, L.M., Pranata R, Diabetes Mellitus Is Associated With Increased Mortality And Severity Of Disease In COVID-19 Pneumonia - A Systematic Review, meta-analysis, and metaregression: Diabetes and COVID-19. Diabetes Metab Syndr Clin Res Rev, 2020. 14(4): p. 395-403.

Jeong IK, Y.K., Lee MK, Diabetes And COVID-19: Global And Regional Perspectives. Diabetes Res Clin Pract;166:108303. https://doi.org/10.1016/j.diabres.2020.108303, 2020.

Parveen R, S.N., Bajpai R, Agarwal NB, Association Of Diabetes And Hypertension With Disease Severity In Covid-19 Patients: A Systematic Literature Review And Exploratory Meta-Analysis. Diabetes Res Clin Pract;166:108295. doi: 10.1016/j.diabres.2020.108295, 2020.

Hussain A, B.B., do Vale Moreira NC, COVID-19 And Diabetes: Knowledge In Progress. Diabetes Res Clin Pract; 162:108142. www.elsevier.com/locate/dissbres, 2020.

Kumar A, A.A., Sharma P, Anikhindi SA, Bansal N, Singla V, Et al, Is Diabetes Mellitus Associated With Mortality And Severity Of COVID-19? A Metaanalysis. Diabetes Metab Syndr Clin Res Rev, 2020. 14(4): p. 535-545.

Kamyshnyi A, K.I., Matskevych V, Marushchak M, Lushchak O, Arterial Hypertension as A Risk Comorbidity Associated With Covid-19 Pathology. J Hypertens. Doi:10.1155/2020/8019360, 2020.

Surendra H, E.I., Djaafara BA, et al, Clinical Characteristics And Mortality Associated With COVID-19 in Jakarta, Indonesia: A Hospital-Based Retrospective Cohortstudy. Lancet Reg Heal - West Pacific;9:100108. doi:10.1016/j.lanwpc.2021.100108, 2021.

Wulandari, W.R.S., Salama N, Hubungan Komorbid Hipertensi dengan Kematian pada Kasus Konfirmasi COVID-19 di DKI Jakarta. Jurnal Ilmu Kesehatan Masyarakat: 287289.http://journals.stikim.ac.id/index.php/jikm, 2021. 10(4).

Pranata R, L.M., Huang I, Raharjo SB, Lukito AA, Hypertension Is Associated With Increased Mortality and Severity Of Disease In COVID-19 Pneumonia: A Systematic Review, Meta-Analysis And Meta-Regression. JRAAS - J Renin-Angiotensin-Aldosterone Syst. Doi:10.1177/1470320320926899, 2020.

Lippi G, W.J., Henry BM, Hypertension And Its Severity Or Mortality In Coronavirus Disease 2019 (COVID-19): A Pooled Analysis. Arch Intern Med. 2020;2019 (March). doi:10.20452/pamw.15272, 2020.

Alfhad H, S.F., Kurniawan B, et al, Dampak Infeksi SARS-Cov-2 Terhadap Penderita Hipertensi Major J;9(April):1-5, 2020.

Perrotta F, C.G., Mazzeo G, et al, COVID-19 And The Elderly: Insights Into Pathogenesis And Clinical Decision-Making. Aging Clin Exp Res. Doi:10.1007/s40520-020-01631-y, 2020.

Casucci G, A.D., Incalzi RA, The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 Patients: Therapeutic Targets. Drugs and Aging. Doi:10.1007/s40266-020-00808-4, 2020.

Downloads

Published

2022-11-29

How to Cite

Amirullah, A. N., Sasmita, S., & Nurmala, D. R. (2022). Host Determinants on Death of Covid-19 Patients. Jurnal EduHealth, 13(02), 736–744. Retrieved from https://ejournal.seaninstitute.or.id/index.php/healt/article/view/800