Evaluation of Potential Drug Interaction in Advanced Phase Tuberculosis Patients at Jember Pulmonary Hospital
Keywords:
Drug Interactions, Tuberculosis, Potential, Advanced Phase, HospitalAbstract
Pulmonary TB is a disease caused by infection from the bacteria Mycobacterium tuberculosis that attacks the lungs. Based on WHO data in Indonesia, the total number of TB cases in 2023 was 1,060,000 cases, the prevalence of TB in the city of Jember was 5,244 cases, and nationally, East Java was in second place based on the estimated incidence of TB with a total of 107,547. From the results of a preliminary study at the Jember Pulmonary Hospital, there were 1,803 cases. This study was to evaluate the interaction of antituberculosis drugs in TB patients at Jember Lung Hospital. The method that will be used by researchers in this study is observation. This type of research is descriptive research with the number of samples used as many as 95 samples using the solvin formula. This study uses random sampling techniques. Data analysis uses univariate analysis, data is displayed in the form of frequency and percentage. Based on the results of the study, the number of men diagnosed with TB was 65%, women were 35%, the results showed that out of 95 tuberculosis patients, 100% of patients experienced potential drug interactions. Based on the severity, major was (65%), moderate was (32%), and minor was (3%), the age range that was more often diagnosed with TB was 17-25, namely 20% and age 55-60 was 28%. Based on the research results that most of the potential drug interactions occur in major interactions. The role of pharmacy in terms of drug interactions is to monitor drug use and regulate drug use scheduling, to avoid drug interactions.
References
Wulandari et al., 2020, menurut WHO, 2023: Kemenkes, 2023 tentang interaksi obat tuberculosis; Dinas Kesehatan Jawa Timur, 2023. Kemenkes, 2020” Pedoman Nasional tahun 2020 klasifikasi pasien TB: Kemenkes RI, 2019, Rachmaniyah, 2017; Menurut Sigalingging et al. 2019” Mar'iyah, K., & Zulkarnain, Z. 2021; Mar'iyah, K., & Zulkarnain, Z. 2021’ S. Sunarmi and K. Kurniawaty, 2022
Dirjen p2p et al, 2023, Tentang data prevalesi TB di jawa timur “ Pedoman Nasional tahun 2020 prevalesi pasien TB.
Dinas Kesehatan Jawa Timur, 2023” data prevalesi TB di jember’ buku pedoman TB di inodonesia tahun 2023.
Santoso rahmat, Elis Susilawati, Elis susanti. 2021. Analisa Pola Penggunaan Dan Kepatuhan Obat Tuberkulosis Di Salah Satu Rumah Sakit Swasta Di Kota Bandung. Universitas Bhakti Kencana.Bandung.
Veryanti Putu Rika, Dewi Kristina Ni Putu, Pertiwi Dian. 2019. Potensi Interaksi Obat Antituberkulosis di instalasi rawat inap RSUD X Jakarta periode 2016. Fakultas Farmasi. Jakarta selatan. Sainstech Farma Vol 12 No 1.
[Rizqiah Ainaya, Damayanti Amitasari. 2022. Review interaksi obat obat potensial terapi antibiotik pada infeksi saluran pernafasan pasien anak rawat inap di rumah sakit. Universitas Hang Tuah Surabaya, Journal Of pharmacy Science And Technology Volume 3 No 2.
Dai, D. et al. 2017,Sasindi et al. 2024’’ Sigalingging et al., 2019. S. Sunarmi and K. Mar'iyah, K., & Zulkarnain, Z. 2021: Kementerian Kesehatan RI, 2014, Kemenkes, 2019; penatalaksaan tuberculosis Puspitaswari, 2021; Rizky et al., 2023” Khoirunnisak, 2021, interaksi obat tuberkulosis” Wicaksana & Rachman, 2018.
[Rahayu Fima Perdani, Yasmiwar Susilawati. 2023. Identifikasi Interaksi Obat Pada Resep Tentang Gangguan Pernafasan Di Bulan Februari 2023 Di Apotek Kota Bandung. Universitas Padjadjaran. Bandung. Jurnal Farmaka Volume 21 No 3.
Kurniawati, Sunarmi. 2022. Hubungan Karakteristik Pasien TB Paru Dengan Kejadian Tuberkulosis. Stikes Aisyiyah Palembang. Volume 7 No 2.
Dian Pertiwi. 2020. Potensi Interaksi Obat Antituberkulosis Di Instalasi Rawat Inap RSUD Jakarta Periode 2020. Sainteh Farma. Jurnal Ilmu Kefarmasian
Ridho Afif Achmad, Damayanti Sri Dini, Indria M.D. 2023. Karakteristik Pasien Tuberkulosis Pada Poli Paru RSUD dr. H. Moh. Anwar Sumenep Periode 28 Juli Sampai 2 Agustus 2023. Fakultas Kedokteran Universitas Islam Malang. Jawa Timur Indonesia.
Kahar Fitriani, Purlinda E.D, Setyowatiningsih Lilik. 2022. Profil Diabetes Melitus Pada Penderita Tuberculosis Paru. Poltekkes Kemenkes Semarang, Prosiding Seminar Nasional Unimus Vol 5.
Arliny Yunita. 2018. Tuberkulosis Dan Diabetes Melitus Implikasi Klinis Dua Epidemik. Universitas Syiah Kuala. Aceh. Jurnal Kedokteran Syiah Kuala Volume 15 No. 1.
Rakhmandani Hafizhah, Nurwulan A.I, Mochammad Hasan, Wafi Alfiah N.S. 2024. Evaluasi Penggunaan Obat Antituberkulosis Paru Pada Pasien AIDS Di Instalasi Rawat Jalan Rumah Sakit Umum Kota Tangerang Selatan. Stikes Widya Dharma Husada Tangerang Banten. Diseminasi Penelitian Pengabdian Masyarakat Vol 1. No 1.
Agrietia, Ade Laksono. 2024. Analisis Karakteristik Pasien Koinfeksi TB-HIV. Universitas Trisakti, Indonesia. Jurnal Research Literate Vol 8 No 5.
Ni'mal Muna, Cahyati Hari W. 2019. Determinan Kejadian Tuberkulosis Pada Orang Dengan HIV/AIDS. Universitas Negeri Semarang. Higeia Journal Of Public Health Research And Development.
Pralia Winda Sari, Sinaga Fransisca. 2022. Pneumonia Komunitas Pada Penderita TBC Kasus Kambuh Dengan DM Tipe 2 (Laporan Kasus). Program Studi Profesi Dokter Universitas Malahayati. Lampung. Jurnal Medika Malahayati, Vol 6, No. 4.
Nurindi Sylvia Fernadya, Himayani R, Prabowo Y A, Yusran, 2018. Hubungan Durasi Penggunaan Etambutol Fase Intensif Kategori 1 Terhadap Persepsi Warna Dan Penuruan Tajam Penglihatan Pada Penderita Tuberkulosis Di Puskesmas Rawat Inap Panjang Kota Bandar Lampung. Universitas Lampung. Artikel Penelitian J Agromedicin Vol 5 No 1.
Fortuna Tista Ayu, Hidajah R, Didik H, Hidayah K. 2022. Studi Pengguaan Obat Antituberkulosis Tahap Lanjutan Pada Pasein Baru BTA Positif. Universitas Muhammdiyah Malang. Jurnal Farmasi Indonesia Vol 19 No 1.
Tanof Putri Varentika, Ika Febrianti B, Idawati T, 2022. Pengaruh Pemberian obat Terapi Obat Antituberkulosis Fase Insentif Terhadap Khualitas Hidup Penderita Tuberkulosis Dikota Upang.Universitas Nusa Cendana. Cendana Medical Journal Edisi 24 No 2.
Abdulkadir Widiyasusanti, Endah N. D. Nur R, Faramitaha. 2022. Gambaran Efek Samping Obat Antituberkulosis Pada Pasien Tuberkulosis. Universitas Negeri Gorontalo. Journal Syifa Seience And Clinical Research. Volume 4 No 1.
Khairunnisa Ayunda Shintani, Irma Melyani P.2023 Review Efek Samping Obat Antituberkulosis Oral Lini Pertama Pada Anak. Universitas Padjajaran. Farmaka Vol 21 No 2.
Agustin Amelia Ovi, Fitrianingsih. 2020. Kajian Interaksi Obat Berdasarkan Kategori Signifikan Klinis Terhadap Pola Peresepan Pasien Rawat Jalan Di Apotek X Jambi. Universitas Jambi. Vol 1 No. 1.
Afrianti Ria, Fatia Larucy, Helen Widayana. 2023. Interaksi Obat Anti Tuberkulosis Pada Pasien Tuberkulosis Paru. Universitas Perintis Indonesia.Sumatera Barat. Jurnal Kesehatan Perintis.
Veryanti Putu Rika, Ni Putu Kristina Dewi, Dian Pertiwi. 2019. Potensi Interaksi Obat Anti Tuberkulosis Di Instalasi Rawat Inap RSUD X Jakarta Periode 2016. Fakultas Farmasi Jakarta Selatan. Jurnal Ilmu Kefarmasian
Putri Randita Vellia, Muslim Zamharira, Avrilya Iqoranny Susilo. 2024. Analisis Kejadian Efek Samping Obat Antituberkulosis Di Kota Bengkulu. Poltekkes Kemenkes Bengkulu. JNPH Vol 12 No 1.
Rahmawati Dwi N, Indah Laily H, Salman. 2023. Review Analisis Efektifitas Dan Risiko Toksisitas Aminofilin Pada Pengobatan Penyakit Asma. Universitas Singbangsa Karanwang. Journal Of Pharmaceutical And Sciences Vol 6 No 1.
Rizki Ziyadatur Maghfiroh L I . 2024. Literatur Review Faktor Resiko Lingkungan Kejadian Tuberkulosis. Universitas Airlangga. Journal Of Public Health Innovation. Vol 4 No 2.
Modul Monitoring Pelayanan Rekam Medis. 2022. Poltekkes Kemenkes Jogjakarta.
Okmina Tri Kusmiyani, Hermanto, Kristin R. 2024. Analisis Faktor Yang Berhubungan Dengan Kepatuhan Minum Obat Anti Tuberkulosis Pada Pasien TB Paru Di Puskesmas Samuda Dan Bapinang Kotawaringin Timur. Stikes Eka Harap, Kalimantan Tengah. Jurnal serga Medika
