SIRT1 As A Novel Therapeutic Target For Periodontitis: A Rapid Review
Keywords:
Periodontitis, sirtuin, SIRT1Abstract
SIRT1 plays a pivotal role in regulating a multitude of biological processes, including cellular metabolism, aging, DNA repair, inflammation, and oxidative stress. evidence suggesting a potential association between SIRT1 activity and periodontal health including periodontitis. This article aims to explore the immunobiological functions of SIRT1 in the initiation and progression of periodontitis. This comprehensive review utilized the PubMed and Cochrane Library databases to collate studies from December 2024 to December 2024. Arround 53 studies were screened and 5 studies were deemed suitable for analyses. Evidence based revealed that, SIRT1 levels elevated after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. Conclussion, clinical studies shows that SIRT1's potential as a biomarker and therapeutic target. Elevated SIRT1 levels after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. However, Prospective studies are necessary to deepen our understanding of their role in the pathophysiology of periodontitis and their potential clinical applications.
References
Caribé, P. M. V., Villar, C. C., Romito, G. A., Pacanaro, A. P., Strunz, C. M. C., Takada, J. Y., Cesar, L. A. M., & Mansur, A. de P. (2020). Influence of the treatment of periodontal disease in serum concentration of sirtuin 1 and mannose-binding lectin. Journal of Periodontology, 91(7), 900–905. https://doi.org/10.1002/JPER.19-0236
Caribé, P. M. V., Villar, C. C., Romito, G. A., Takada, J. Y., Pacanaro, A. P., Strunz, C. M. C., César, L. A. M., & Mansur, A. de P. (2020a). Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery disease. Therapeutic Advances in Chronic Disease, 11, 2040622320919621. https://doi.org/10.1177/2040622320919621
Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J., & Liu, L. F. (2016). 2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis. Mediators of Inflammation, 2016, 6953459. https://doi.org/10.1155/2016/6953459
Correâ, M. G., Pires, P. R., Ribeiro, F. V., Pimentel, S. P., Cirano, F. R., Napimoga, M. H., Casati, M. Z., & Casarin, R. C. V. (2018). Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats. PLoS ONE, 13(10), e0204414. https://doi.org/10.1371/JOURNAL.PONE.0204414
Dascalu, L. M., Moldovan, M., Sarosi, C., Sava, S., Dreanca, A., Repciuc, C., Purdoiu, R., Nagy, A., Badea, M. E., Paun, A. G., Badea, I. C., & Chifor, R. (2022). Photodynamic Therapy with Natural Photosensitizers in the Management of Periodontal Disease Induced in Rats. Gels 2022, Vol. 8, Page 134, 8(2), 134. https://doi.org/10.3390/GELS8020134
He, Y., Wang, Y., Jia, X., Li, Y., Yang, Y., Pan, L., Zhao, R., Han, Y., Wang, F., Guan, X., & Hou, T. (2023). Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway. International Immunopharmacology, 119. https://doi.org/10.1016/J.INTIMP.2023.110192
Kluknavská, J., Krajčíková, K., Bolerázska, B., Mašlanková, J., Ohlasová, J., Timková, S., Drotárová, Z., & Vašková, J. (2021). Possible prognostic biomarkers of periodontitis in saliva. European Review for Medical and Pharmacological Sciences, 25(8), 3154–3161. https://doi.org/10.26355/EURREV_202104_25724
Kriaučiūnas, A., Liutkevičienė, R., Gedvilaitė, G., Kaikarytė, K., Vilkevičiūtė, A., Gleiznys, D., Pacauskienė, I., & Žekonis, G. (2022). Value of Serum Sirtuin-1 (SIRT1) Levels and SIRT1 Gene Variants in Periodontitis Patients. Medicina, 58(5), 653. https://doi.org/10.3390/MEDICINA58050653
Kudo, H., Takeichi, O., Hatori, K., Makino, K., Himi, K., & Ogiso, B. (2018). A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis. International Endodontic Journal, 51(7), 747–757. https://doi.org/10.1111/IEJ.12894
Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015a). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1), 1–9. https://doi.org/10.1186/2046-4053-4-1
Pan, Z., Dong, H., Huang, N., & Fang, J. (2022). Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases. Frontiers in Physiology, 13. https://doi.org/10.3389/FPHYS.2022.953078
Sun, H., Li, D., Wei, C., Liu, L., Xin, Z., Gao, H., & Gao, R. (2024). The relationship between SIRT1 and inflammation: a systematic review and meta-analysis. Frontiers in Immunology, 15, 1465849. https://doi.org/10.3389/FIMMU.2024.1465849/BIBTEX
Tamaki, N., Cristina Orihuela-Campos, R., Inagaki, Y., Fukui, M., Nagata, T., & Ito, H. O. (2014). Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model. Free Radical Biology & Medicine, 75, 222–229. https://doi.org/10.1016/J.FREERADBIOMED.2014.07.034
Yang, B., Pang, X., Li, Z., Chen, Z., & Wang, Y. (2021). Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives. Frontiers in Immunology, 12, 781378. https://doi.org/10.3389/FIMMU.2021.781378/BIBTEX
Ye, Q., Xu, H., Liu, S., Li, Z., Zhou, J., Ding, F., Zhang, X., Wang, Y., Jin, Y., & Wang, Q. (2022). Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammatory responses of macrophages via AMPK/SIRT1/NF-κB pathway and inhibit osteoclast formation. Journal of Periodontology, 93(11), 1738–1751. https://doi.org/10.1002/JPER.21-0657
