A Review Of IL-17 Relation With Microbiome In Metabolic Disorder

Authors

  • Nuroh Najmi Anatomy Pathology, Department of Oral Biology, Faculty of Dentistry Universitas Padjadjaran
  • Faisal Kuswandani Pharmacy, Department of Oral Biology Faculty of Dentistry Universitas Padjadjaran, Indonesia
  • Anggun Rafisa Physiology, Department of Oral Biology Faculty of Dentistry Universitas Padjadjaran, Indonesia
  • Falisha Febriane Balafif Microbiology, Department of Oral Biology Faculty of Dentistry Universitas Padjadjaran, Indonesia

Keywords:

IL-17, microbiome, metabolic diseases, cytokine

Abstract

The relationship between IL-17 and the microbiome remains an area requiring extensive research. IL-17, a pro-inflammatory cytokine, plays a crucial role in immune function, particularly in its interactions with the microbiome, especially within the intestinal digestive system. In metabolic diseases linked to inflammation, this connection underscores the importance of understanding cytokine activity and the microbiome's response within the body. In this literature review, three articles were retrieved from a single database, exploring the relationship between IL-17, metabolic diseases, and the microbiome.

References

Alam A, Neish A. (2003). Role of gut microbiota in intestinal wound healing and barrier function. Tissue Barriers, 6:1539595.

Najmi, N., Megantara, I., Andriani, L., Goenawan, H., Lesmana, R. 2022. Importance of gut microbiome regulation for the prevention and recovery process after SARS-CoV-2 respiratory viral infection (Review). Biomed Rep 16(4):25. doi: 10.3892/br.2022.1508

Bencara, H., McGeachy, MJ., Gaffen, SL. 2021. The metabolism-modulating activity of IL-17 signaling in health and disease. J Exp Med. 218 (5): 320202191

Li, P., Lu,H., Wu, H ,. Huang S., Chen L , Qifeng Gui Q ., Zhou W ., Yang Y , Wu Y , Zhang H, Zhang Q ., Yang H. 2020. Periodontitis in elderly patients with type 2 diabetes mellitus: impact on gut microbiota and systemic inflammation. Aging, 12(24): 25956- 25980

Hu S, Vila AV, Gacesa R., Collij V., et al. 2021. Whole exome sequencing analyses reveal gene– microbiota interactions in the context of IBD. Gut; 70:285–296. doi:10.1136/gutjnl-2019-319706.

Kumar, PS., Monteiro, MF., Casari, RCV. Subgingival Host-Microbial Interactions in Hyperglycemic Individuals. Journal of Dental Research, 99 (6).

Pircalabioru, GG., Grigore, GA., Barbu, IC., Chifiriuc, MC., Savu O. 2023. Impact of COVID-19 on the Microbiome and Inflammatory Status of Type 2 Diabetes Patients. Biomedicines; 11(179). https://doi.org/10.3390/biomedicines11010179

Garidou L, Pomié C, Klopp P, et al. The gut microbiota regulates intestinal CD4 T cells expressing RORgt and controls metabolic disease. Cell Metab 2015; 22:100–112

Humans Xin Zhou., Jethro S. Johnson., Daniel Spakowicz., Wenyu Zhou., Yanjiao Zhou., Erica Sodergren., Michael Snyder., George M. Weinstock. 2023. Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With Clostridia and Insulin Sensitivity in Humans. Diabetes 2020;69:1833–1842. https://doi.org/10.2337/db19-0592.

Wang, CH., Yen, HR., Lu WL., Ho, HH., Kuo, YW., Huang, YY., Tsai SY., Lin, HC. 2022. Adjuvant Probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients with Type 1 Diabetes Mellitus. Front. Endocrinol. 13:754401. doi: 10.3389/fendo.2022.754401.

Hadian, Y., Bagood, MD., Dahle, SE., Sood, A., Isseroff, RR. 2019. Interleukin-17: Potential Target for Chronic Wounds. Mediators of Inflammation, 1-10

Boulangé, CL ., Luisa Neves, AL., Chilloux, J., Jeremy K. Nicholson, JK. Dumas, ME. 2016. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Medicine. 8:42 DOI 10.1186/s13073-016-0303-2.

Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–45. doi:10.1146/annurev-immunol-031210-101322.

Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761–72. doi:10.2337/db06-1491.

Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. Minireview: Gut microbiota: the neglected endocrine organ. Mol Endocrinol. 2014;28:1221–38. doi:10.1210/me.2014-1108.

Mobarrez, BD., Kariminik, A. 2017. Gut Microbiota and IL-17A: Physiological and Pathological Responses. Probiotics & Antimicro. Prot. DOI 10.1007/s12602-017-9329-z.

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Published

2024-12-31

How to Cite

Najmi, N., Kuswandani , F., Rafisa, A., & Falisha Febriane Balafif. (2024). A Review Of IL-17 Relation With Microbiome In Metabolic Disorder . Jurnal EduHealth, 15(04), 1173–1178. Retrieved from https://ejournal.seaninstitute.or.id/index.php/healt/article/view/6086

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